Melanoma stem cells

被引：3

作者：

Roesch, Alexander ^{[1
]}

机构：

[1] Univ Klinikum Essen, Klin & Poliklin Dermatol Allergol & Venerol, D-45122 Essen, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2015年 / 13卷 / 02期

关键词：

TUMOR-GROWTH; CANCER; HETEROGENEITY; MUTATIONS; THERAPY; DIFFERENTIATION; TUMORIGENESIS; SUBPOPULATION; MAINTENANCE;

D O I：

10.1111/ddg.12584_suppl

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The cancer stem cell concept significantly broadens our understanding of melanoma biology. However, this concept should be regarded as an integral part of a holistic cancer model that also includes the genetic evolution of tumor cells and the variability of cell phenotypes within a dynamic tumor microenvironment. The biologic complexity and methodological difficulties in identifying cancer stem cells and their biomarkers are currently impeding the direct translation of experimental findings into clinical practice. Nevertheless, it is these methodological shortcomings that provide a new perspective on the phenotypic heterogeneity and plasticity of melanoma with important consequences for future therapies. The development of new combination treatment strategies, particularly with regard to overcoming treatment resistance, could significantly benefit from targeted elimination of cell subpopulations with cancer stem cell properties.

引用

页码：118 / 124

页数：7

共 41 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Melanoma genome sequencing reveals frequent PREX2 mutations [J].

Berger, Michael F. ;

Hodis, Eran ;

Heffernan, Timothy P. ;

Deribe, Yonathan Lissanu ;

Lawrence, Michael S. ;

Protopopov, Alexei ;

Ivanova, Elena ;

Watson, Ian R. ;

Nickerson, Elizabeth ;

Ghosh, Papia ;

Zhang, Hailei ;

Zeid, Rhamy ;

Ren, Xiaojia ;

Cibulskis, Kristian ;

Sivachenko, Andrey Y. ;

Wagle, Nikhil ;

Sucker, Antje ;

Sougnez, Carrie ;

Onofrio, Robert ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Fennell, Timothy ;

Carter, Scott L. ;

Drier, Yotam ;

Stojanov, Petar ;

Singer, Meredith A. ;

Voet, Douglas ;

Jing, Rui ;

Saksena, Gordon ;

Barretina, Jordi ;

Ramos, Alex H. ;

Pugh, Trevor J. ;

Stransky, Nicolas ;

Parkin, Melissa ;

Winckler, Wendy ;

Mahan, Scott ;

Ardlie, Kristin ;

Baldwin, Jennifer ;

Wargo, Jennifer ;

Schadendorf, Dirk ;

Meyerson, Matthew ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Wagner, Stephan N. ;

Lander, Eric S. ;

Getz, Gad ;

Chin, Lynda ;

Garraway, Levi A. .

NATURE, 2012, 485 (7399) :502-506

[3]

Boiko AD, NATURE, V466, P133

[4] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[5] Melanoma Chemotherapy Leads to the Selection of ABCB5-Expressing Cells [J].

Chartrain, Marine ;

Riond, Joele ;

Stennevin, Aline ;

Vandenberghe, Isabelle ;

Gomes, Bruno ;

Lamant, Laurence ;

Meyer, Nicolas ;

Gairin, Jean Edouard ;

Guilbaud, Nicolas ;

Annereau, Jean Philippe .

PLOS ONE, 2012, 7 (05)

[6] CD271 is an imperfect marker for melanoma initiating cells [J].

Cheli, Yann ;

Bonnazi, Vanessa F. ;

Jacquel, Arnaud ;

Allegra, Maryline ;

De Donatis, Gian Marco ;

Bahadoran, Philippe ;

Bertolotto, Corine ;

Ballotti, Robert .

ONCOTARGET, 2014, 5 (14) :5272-5283

[7] A restricted cell population propagates glioblastoma growth after chemotherapy [J].

Chen, Jian ;

Li, Yanjiao ;

Yu, Tzong-Shiue ;

McKay, Renee M. ;

Burns, Dennis K. ;

Kernie, Steven G. ;

Parada, Luis F. .

NATURE, 2012, 488 (7412) :522-+

[8] Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth [J].

Civenni, Gianluca ;

Walter, Anne ;

Kobert, Nikita ;

Mihic-Probst, Daniela ;

Zipser, Marie ;

Belloni, Benedetta ;

Seifert, Burkhardt ;

Moch, Holger ;

Dummer, Reinhard ;

van den Broek, Maries ;

Sommer, Lukas .

CANCER RESEARCH, 2011, 71 (08) :3098-3109

[9]

Clarke Michael F, 2006, Cancer Res, V66, P9339, DOI 10.1158/0008-5472.CAN-06-3126

[10] The cancer stem cell: premises, promises and challenges [J].

Clevers, Hans .

NATURE MEDICINE, 2011, 17 (03) :313-319

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