Association of hemoglobin glycation index with cardiovascular risk factors in non-diabetic adults: A cross-sectional study

Background and aims: The study aimed to explore the association of hemoglobin glycation index (HGI) with cardiovascular risk factors in non-diabetic adults. Methods: This cross-sectional study included 200 adults of 20-60 years of age. Predicted glycated he-moglobin (HbA1c) was calculated from linear regression equation. HGI was calculated using the formula HGI 1/4 measured HbA1c-predicted HbA1c. The study subjects were classified into three groups based on their HGI tertiles. Cardiovascular risk factors were compared between the groups and Pearson correlation test was done to correlate HGI with cardiovascular risk factors. Results: Serum total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) showed significant increase with increase in HGI in non diabetic individuals. High HGI group had significantly high serum total cholesterol, triglyceride, LDL-C and VLDL-C compared to low HGI group. Serum total cholesterol, triglyceride, LDL-C and VLDL-C showed a statistically significant positive correlation with HGI. Conclusion: We have found a statistically significant correlation of HGI with serum lipid profile, a significant cardiovascular risk factor in non-diabetic individuals. HGI, a simple derivative of HbA1c and fasting plasma glucose may be used to identify cardiovascular risk in non-diabetic individuals. Further prospective studies are required in larger sample size to confirm the clinical implications of HGI.(c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.