Organometallic palladium and platinum complexes with strongly donating alkyl coligands - Synthesis, structures, chemical and cytotoxic properties

被引：34
作者：
Klein, Axel [1 ]
Luening, Anna [1 ]
Ott, Ingo [2 ]
Hamel, Laura [2 ]
Neugebauer, Michael [1 ]
Butsch, Katharina [1 ]
Lingen, Verena [1 ]
Heinrich, Frank [1 ]
Elmas, Said [1 ]
机构：
[1] Univ Cologne, Dept Chem, Inst Inorgan Chem, D-50939 Cologne, Germany
[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Chem, D-38106 Braunschweig, Germany
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2010年 / 695卷 / 15-16期
关键词：
Organopalladium; Organoplatinum; Alkyl ligands; Alkynyl ligands; Transmetallation reactions; Cytotoxicity; INSERTION REACTIONS; THERMAL-DECOMPOSITION; MOLECULAR-STRUCTURE; LIGANDS; ACTIVATION; REACTIVITY; ALKENE; ARYL; ORGANOPLATINUM(II); ELIMINATION;
D O I：
10.1016/j.jorganchem.2010.04.027
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis, spectroscopy, and structures of organometallic complexes [(COD)M(R)X] and [(COD)M(R)(R')] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = methyl, neopentyl (2,2-dimethylpropyl), neosilyl (trimethylsilylmethyl), or benzyl; X = Cl, Br, or I; R' = 2-phenyl-ethynyl, p-fluoro-2-phenyl-ethynyl, p-methyl-2-phenyl-ethynyl or p-nitro-2-phenyl-ethynyl) has been explored. Selected samples of organo-platinum complexes show strikingly high cytotoxicity when tested against HT-29 and MCF-7 tumour cells. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1898 / 1905
页数：8
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