Organometallic palladium and platinum complexes with strongly donating alkyl coligands - Synthesis, structures, chemical and cytotoxic properties

被引：34

作者：

Klein, Axel ^{[1
]}

Luening, Anna ^{[1
]}

Ott, Ingo ^{[2
]}

Hamel, Laura ^{[2
]}

Neugebauer, Michael ^{[1
]}

Butsch, Katharina ^{[1
]}

Lingen, Verena ^{[1
]}

Heinrich, Frank ^{[1
]}

Elmas, Said ^{[1
]}

机构：

[1] Univ Cologne, Dept Chem, Inst Inorgan Chem, D-50939 Cologne, Germany

[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Chem, D-38106 Braunschweig, Germany

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2010年 / 695卷 / 15-16期

关键词：

Organopalladium; Organoplatinum; Alkyl ligands; Alkynyl ligands; Transmetallation reactions; Cytotoxicity; INSERTION REACTIONS; THERMAL-DECOMPOSITION; MOLECULAR-STRUCTURE; LIGANDS; ACTIVATION; REACTIVITY; ALKENE; ARYL; ORGANOPLATINUM(II); ELIMINATION;

D O I：

10.1016/j.jorganchem.2010.04.027

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis, spectroscopy, and structures of organometallic complexes [(COD)M(R)X] and [(COD)M(R)(R')] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = methyl, neopentyl (2,2-dimethylpropyl), neosilyl (trimethylsilylmethyl), or benzyl; X = Cl, Br, or I; R' = 2-phenyl-ethynyl, p-fluoro-2-phenyl-ethynyl, p-methyl-2-phenyl-ethynyl or p-nitro-2-phenyl-ethynyl) has been explored. Selected samples of organo-platinum complexes show strikingly high cytotoxicity when tested against HT-29 and MCF-7 tumour cells. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1898 / 1905

页数：8

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