Evaluation of Ruthenium(II) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase

被引：12

作者：

Burmeister, Hilke ^{[1
]}

Dietze, Pascal ^{[2
]}

Preu, Lutz ^{[1
]}

Bandow, Julia E. ^{[2
]}

Ott, Ingo ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany

[2] Ruhr Univ Bochum, Fac Biol & Biotechnol, Appl Microbiol, Univ Str 150, D-44801 Bochum, Germany

来源：

MOLECULES | 2021年 / 26卷 / 14期

关键词：

antibacterial; N-heterocyclic carbenes; ruthenium; thioredoxin reductase; PROTEIN INTERACTIONS; GOLD(I) COMPLEXES; CELLULAR UPTAKE; RHODIUM(I); CYTOTOXICITY; LIGANDS; THIOL;

D O I：

10.3390/molecules26144282

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(II)X-2 (where X = halide) was prepared, characterized, and evaluated as antibacterial agents in comparison to the respective metal free benzimidazolium cations. The ruthenium(II) NHC complexes generally triggered stronger bacterial growth inhibition than the metal free benzimidazolium cations. The effects were much stronger against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) than against Gram-negative bacteria (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa), and all complexes were inactive against the fungus Candida albicans. Moderate inhibition of bacterial thioredoxin reductase was confirmed for selected complexes, indicating that inhibition of this enzyme might be a contributing factor to the antibacterial effects.

引用

页数：11

共 33 条

[1] Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups [J].

Albada, H. Bauke ;

Chiriac, Alina-Iulia ;

Wenzel, Michaela ;

Penkova, Maya ;

Bandow, Julia E. ;

Sahl, Hans-Georg ;

Metzler-Nolte, Nils .

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2012, 8 :1753-1764

[2]

[Anonymous], 2016, GAUSSIAN 16 REV B01

[3] Ru(ii)-N-heterocyclic carbene complexes: synthesis, characterization, transfer hydrogenation reactions and biological determination [J].

Boubakri, Lamia ;

Chakchouk-Mtibaa, A. ;

Al-Ayed, Abdullah S. ;

Mansour, L. ;

Abutaha, Nael ;

Harrath, Abdel Halim ;

Mellouli, L. ;

Ozdemir, I. ;

Yasar, S. ;

Hamdi, Naceur .

RSC ADVANCES, 2019, 9 (59) :34406-34420

[4]

Cetinkaya B, 1996, ARZNEIMITTEL-FORSCH, V46, P821

[5] A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway [J].

Dabiri, Yasamin ;

Schmid, Alice ;

Theobald, Jannick ;

Blagojevic, Biljana ;

Streciwilk, Wojciech ;

Ott, Ingo ;

Woelfl, Stefan ;

Cheng, Xinlai .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)

[6] A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level [J].

Daubit, Isabelle M. ;

Sullivan, Matthew P. ;

John, Milena ;

Goldstone, David C. ;

Hartinger, Christian G. ;

Metzler-Nolte, Nils .

INORGANIC CHEMISTRY, 2020, 59 (23) :17191-17199

[7] Unveiling Luminescent IrI and RhI N-Heterocyclic Carbene Complexes: Structure, Photophysical Specifics, and Cellular Localization in the Endoplasmic Reticulum [J].

Daubit, Isabelle Marie ;

Wortmann, Svenja ;

Siegmund, Daniel ;

Hahn, Stephan ;

Nuernberger, Patrick ;

Metzler-Nolte, Nils .

CHEMISTRY-A EUROPEAN JOURNAL, 2021, 27 (22) :6783-6794

[8] Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N-Heterocyclic Carbene Complexes [J].

Gothe, Yvonne ;

Marzo, Tiziano ;

Messori, Luigi ;

Metzler-Nolte, Nils .

CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (35) :12487-12494

[9] A focus on the biological targets for coinage metal-NHCs as potential anticancer complexes [J].

Guarra, Federica ;

Pratesi, Alessandro ;

Gabbiani, Chiara ;

Biver, Tarita .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2021, 217

[10] Novel Ruthenium(II) and Gold(I) NHC Complexes: Synthesis, Characterization, and Evaluation of Their Anticancer Properties [J].

Hackenberg, Frauke ;

Mueller-Bunz, Helge ;

Smith, Raymond ;

Streciwilk, Wojciech ;

Zhu, Xiangming ;

Tacke, Matthias .

ORGANOMETALLICS, 2013, 32 (19) :5551-5560

← 1 2 3 4 →