Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents#

被引:19
作者
de Oya, Iria [1 ]
Schoppen, Stefanie [1 ]
Lasuncion, Miguel A. [2 ,3 ]
Lopez-Simon, Laura [1 ]
Riestra, Pia [1 ]
de Oya, Manuel [1 ]
Garces, Carmen [1 ]
机构
[1] Fdn Jimenez Diaz, Lipid Res Lab, E-28040 Madrid, Spain
[2] Univ Alcala, Serv Bioquim Invest, Hosp Ramon y Cajal, Madrid 28034, Spain
[3] ISCIII, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain
关键词
adolescents; HOMA; insulin; MS; SHBG; INSULIN-RESISTANCE; TOTAL TESTOSTERONE; HEALTHY-CHILDREN; MODEL ASSESSMENT; OBESITY; WOMEN; INDEX; MEN; HYPERINSULINEMIA; ASSOCIATION;
D O I
10.1111/j.1399-5448.2009.00559.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Low levels of sex hormone-binding globulin (SHBG) are associated with obesity, insulin resistance, and metabolic syndrome (MS) in men and women, and it has been suggested that SHBG could be a useful marker for MS risk. Objective: The aim of this study was to analyze the relationship of SHBG levels with MS and its components in Spanish adolescents. Methods: The sample population of this cross-sectional study was comprised of 386 male and 429 female adolescents, aged 12-16 yr. Anthropometric parameters and blood pressure (BP) were measured. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, insulin, glucose, and SHBG levels were determined. The pediatric International Diabetes Federation (IDF) definition was used to classify adolescents for MS. Results: SHBG levels were lower in adolescents with MS or with some MS features. More than 90% of the abdominally obese adolescents were in the lowest and medium SHBG tertiles. In girls, BP was significantly higher in the lowest SHBG tertile than in the two others, whereas in boys BP levels were significantly higher in the lowest and medium tertiles than in the highest one. Insulin levels and homeostasis model assessment (HOMA) index were also significantly higher in the lowest SHBG tertile than in the two others. Conclusions: The associations of SHBG with MS and its components, such as abdominal obesity, high BP or insulin levels, are already present in normal adolescents. This may suggest the possibility of using SHBG levels as a biomarker for MS risk in adolescents as well as adults.
引用
收藏
页码:188 / 194
页数:7
相关论文
共 34 条
[1]   Racial difference in circulating sex hormone-binding globulin levels in prepubertal boys [J].
Abdelrahaman, A ;
Raghavan, S ;
Baker, L ;
Weinrich, M ;
Winters, SJ .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (01) :91-96
[2]   SEX-HORMONE-BINDING GLOBULIN [J].
ANDERSON, DC .
CLINICAL ENDOCRINOLOGY, 1974, 3 (01) :69-96
[3]  
Atabek ME, 2007, J PEDIATR ENDOCR MET, V20, P187
[4]   Sex hormone-binding globulin is a major determinant of the lipid profile:: the PRIME study [J].
Bataille, V ;
Perret, B ;
Evans, A ;
Amouyel, P ;
Arveiler, D ;
Ducimetière, P ;
Bard, JM ;
Ferrières, J .
ATHEROSCLEROSIS, 2005, 179 (02) :369-373
[5]  
Celik T., 2008, INT J CARDIOL
[6]   Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS [J].
Chen, Mei-Jou ;
Yang, Wei-Shiung ;
Yang, Jehn-Hsiahn ;
Hsiao, Chuhsing Kate ;
Yang, Yu-Shih ;
Ho, Hong-Nerng .
HUMAN REPRODUCTION, 2006, 21 (09) :2266-2271
[7]   Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study [J].
Chubb, S. A. Paul ;
Hyde, Zoe ;
Almeida, Osvaldo P. ;
Flicker, Leon ;
Norman, Paul E. ;
Jamrozik, Konrad ;
Hankey, Graeme J. ;
Yeap, Bu B. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (06) :785-792
[8]   Sex hormone-binding globulin and testosterone in individuals with childhood diabetes [J].
Danielson, Kirstie K. ;
Drum, Melinda L. ;
Lipton, Rebecca B. .
DIABETES CARE, 2008, 31 (06) :1207-1213
[9]   Sex hormone binding globulin concentration as a prepubertal marker for hyperinsulinaemia in obesity [J].
Galloway, PJ ;
Donaldson, MDC ;
Wallace, AM .
ARCHIVES OF DISEASE IN CHILDHOOD, 2001, 85 (06) :489-491
[10]   Hormone levels in 12-to 15-year-old boys and girls in Spain and their relationship with anthropometric variables [J].
Garces, Carmen ;
de Oya, Iria ;
Lopez-Simon, Laura ;
Cano, Beatriz ;
Schoppen, Stefanie ;
Gil, Angel ;
de Oya, Manuel .
CLINICAL BIOCHEMISTRY, 2008, 41 (7-8) :621-624