dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma1 receptor activation in the rat

被引：13

作者：

Wu, Hsiang-En ^{[1
]}

Schwasinger, Emma. T. ^{[1
]}

Terashvili, Maia ^{[1
]}

Tseng, Leon F. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 562卷 / 03期

关键词：

sigma receptor; addiction; opioid; morphine; (rat);

D O I：

10.1016/j.ejphar.2007.01.083

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to 3 mu g/kg given subcutaneously dose-dependently attenuated the morphine-produced conditioned place preference. However, dextro-morphine at a higher dose 100 mu g/kg did not affect the morphine-produced conditioned place preference. Thus, dextro-morphine pretreatment induces a U-shaped dose-response curve for attenuating the morphine-produced conditioned place preference. The attenuation of the morphine-produced conditioned place preference was reversed by the pretreatment with the sigma I receptor antagonist BD1047 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. dextro-Morphine or BD1047 given alone did not affect the baseline place conditioning. It is concluded that dextro-morphine attenuated the morphine-produced conditioned place preference via the sigma, receptor activation. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：221 / 226

页数：6

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