miRNA in a multiomic context for diagnosis, treatment monitoring and personalized management of metastatic breast cancer

被引：25

作者：

Zubor, Pavol ^{[1
,2
]}

Kubatka, Peter ^{[2
,3
]}

Dankova, Zuzana ^{[2
]}

Gondova, Alexandra ^{[1
]}

Kajo, Karol ^{[4
,5
]}

Hatok, Jozef ^{[6
]}

Samec, Marek ^{[1
,2
]}

Jagelkova, Marianna ^{[1
,2
]}

Krivus, Stefan ^{[1
]}

Holubekova, Veronika ^{[2
]}

Bujnak, Jan ^{[7
,8
]}

Laucekova, Zuzana ^{[1
]}

Zelinova, Katarina ^{[1
,2
]}

Stastny, Igor ^{[1
,2
]}

Nachajova, Marcela ^{[1
]}

Danko, Jan ^{[1
]}

Golubnitschaja, Olga ^{[9
,10
,11
]}

机构：

[1] Comenius Univ, Martin Univ Hosp, Jessenius Fac Med, Dept Obstet & Gynecol, Martin, Slovakia

[2] Comenius Univ, Biomed Ctr Martin, Jessenius Fac Med, Div Oncol, Martin, Slovakia

[3] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Martin, Slovakia

[4] St Elizabeth Canc Inst Hosp, Dept Pathol, Bratislava, Slovakia

[5] Slovak Acad Sci, Biomed Res Ctr, Bratislava, Slovakia

[6] Comenius Univ, Jessenius Fac Med, Dept Med Biochem, Martin, Slovakia

[7] Kukuras Michalovce Hosp, Dept Obstet & Gynecol, Michalovce, Slovakia

[8] Penta Hosp Int, Svet Zdravia, Oncogynecol Unit, Michalovce, Slovakia

[9] Rhein Friedrich Wilhelms Univ Bonn, Radiol Clin, Bonn, Germany

[10] Rhein Friedrich Wilhelms Univ Bonn, Breast Canc Res Ctr, Bonn, Germany

[11] Rhein Friedrich Wilhelms Univ Bonn, Ctr Integrated Oncol, Bonn, Germany

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 18期

关键词：

breast cancer; individual outcome; metastasis; miRNA; personalized medicine; prediction; prevention; GENE-EXPRESSION PATTERNS; CIRCULATING MICRORNAS; INTRINSIC-SUBTYPES; PROGNOSTIC VALUE; CELL-FREE; NEOADJUVANT CHEMOTHERAPY; DIFFERENTIAL EXPRESSION; MOLECULAR PORTRAITS; FLAMMER SYNDROME; GENOMIC MAPS;

D O I：

10.2217/fon-2018-0061

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic breast cancer is characterized by aggressive spreading to distant organs. Despite huge multilevel research, there are still several important challenges that have to be clarified in the management of this disease. Therefore, recent investigations have implemented a modern, multiomic approach with the aim of identifying specific biomarkers for not only early detection but also to predict treatment responses and metastatic spread. Specific attention is paid to short miRNAs, which regulate gene expression at the post-transcriptional level. Aberrant miRNA expression could initiate cancer development, cell proliferation, invasion, migration, metastatic spread or drug resistance. An miRNA signature is, therefore, believed to be a promising biomarker and prediction tool that could be utilized in all phases of carcinogenesis. This article offers comprehensive information about miRNA profiles useful for diagnostic and treatment purposes that may sufficiently advance breast cancer management and improve individual outcomes in the near future.

引用

页码：1846 / 1866

页数：21

共 195 条

[21] Descriptive analysis of estrogen receptor (ER)negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype - A population-based study from the California Cancer Registry [J].