Correlates of Circulating 25-Hydroxyvitamin D

被引：108

作者：

McCullough, Marjorie L. ^{[1
]}

Weinstein, Stephanie J. ^{[2
]}

Freedman, D. Michal ^{[2
]}

Helzlsouer, Kathy ^{[3
,4
]}

Flanders, W. Dana ^{[5
]}

Koenig, Karen ^{[6
,7
,8
]}

Kolonel, Laurence ^{[9
]}

Laden, Francine ^{[10
,11
,12
,13
]}

Le Marchand, Loic ^{[9
]}

Purdue, Mark ^{[2
]}

Snyder, Kirk ^{[14
]}

Stevens, Victoria L. ^{[1
]}

Stolzenberg-Solomon, Rachael ^{[2
]}

Virtamo, Jarmo ^{[15
]}

Yang, Gong ^{[16
]}

Yu, Kai ^{[2
]}

Zheng, Wei ^{[16
]}

Albanes, Demetrius ^{[2
]}

Ashby, Jason ^{[14
]}

Bertrand, Kimberly ^{[13
]}

Cai, Hui ^{[16
]}

Chen, Yu ^{[6
,7
,8
]}

Gallicchio, Lisa ^{[3
,4
]}

Giovannucci, Edward ^{[13
,17
]}

Jacobs, Eric J. ^{[1
]}

Hankinson, Susan E. ^{[10
,11
,13
]}

Hartge, Patricia ^{[2
]}

Hartmuller, Virginia ^{[18
]}

Harvey, Chinonye ^{[19
]}

Hayes, Richard B. ^{[6
,7
,8
]}

Horst, Ronald L. ^{[20
]}

Shu, Xiao-Ou ^{[16
]}

机构：

[1] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA

[2] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[3] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[5] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[6] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[7] NYU, Sch Med, Dept Med, New York, NY USA

[8] NYU, Inst Canc, New York, NY USA

[9] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[10] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[11] Harvard Univ, Sch Med, Boston, MA USA

[12] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Informat Management Serv Inc, Silver Spring, MD USA

[15] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[16] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, Nashville, TN 37212 USA

[17] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[18] Sci Consulting Grp Inc, Gaithersburg, MD USA

[19] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[20] Heartland Assays Inc, Ames, IA USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

body mass index; cohort studies; diet; dietary supplements; ethnic groups; exercise; seasons; vitamin D; VITAMIN-D STATUS; D INSUFFICIENCY; DIETARY-INTAKE; BODY-FAT; ELDERLY POPULATION; US POPULATION; UNITED-STATES; D DEFICIENCY; WOMEN; DETERMINANTS;

D O I：

10.1093/aje/kwq113

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geographic area. Demographic and lifestyle characteristics were examined in relation to 25(OH)D using stepwise linear regression and polytomous logistic regression. The prevalence of 25(OH)D concentrations less than 25 nmol/L ranged from 3% to 36% across cohorts, and the prevalence of 25(OH)D concentrations less than 50 nmol/L ranged from 29% to 82%. Seasonal differences in circulating 25(OH)D were most marked among whites from northern latitudes. Statistically significant positive correlates of 25(OH)D included male sex, summer blood draw, vigorous physical activity, vitamin D intake, fish intake, multivitamin use, and calcium supplement use. Significant inverse correlates were body mass index, winter and spring blood draw, history of diabetes, sedentary behavior, smoking, and black race/ethnicity. Correlates varied somewhat within season, race/ethnicity, and sex. These findings help identify persons at risk for low vitamin D status for both clinical and research purposes.

引用

页码：21 / 35

页数：15

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