Effect of Subthalamic Nucleus Stimulation on Pedunculopontine Nucleus Neural Activity

被引：6

作者：

Sitti, Ilkay ^{[1
]}

Acar, Goksemin ^{[2
]}

Zisakis, Athanasios K. ^{[1
]}

Ozdemir, Mevci ^{[1
]}

Acar, Feridun ^{[1
]}

Burchiel, Kim J. ^{[3
]}

机构：

[1] Pamukkale Univ, Fac Med, Dept Neurosurg, TR-20070 Kinikli, Denizli, Turkey

[2] Pamukkale Univ, Fac Med, Dept Neurol, Kinikli, Denizli, Turkey

[3] Oregon Hlth & Sci Univ, Dept Neurosurg, Portland, OR 97201 USA

来源：

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | 2016年 / 94卷 / 01期

关键词：

Parkinson's disease; Deep brain stimulation; Microelectrode recording; Subthalamic nucleus; Pedunculopontine nucleus; Globus pallidus internus; DEEP BRAIN-STIMULATION; LOW-FREQUENCY STIMULATION; BASAL GANGLIA; PARKINSONS-DISEASE; TEGMENTAL NUCLEUS; SUBSTANTIA-NIGRA; GAIT; NEURONS; REGION; PHYSIOLOGY;

D O I：

10.1159/000442892

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The pedunculopontine nucleus has recently been proposed as an alternative target for deep brain stimulation for the treatment of medically intractable Parkinson's disease. The suggested indication for pedunculopontine nucleus deep brain stimulation is severe and medically intractable axial symptoms such as gait and postural impairment. Objective: Our goal in this study was to describe the effects of subthalamic nucleus stimulation on pedunculopontine nucleus electrophysiological activity. Methods: Fourteen male Wistar rats were divided into a sham stimulation group and an experimental group. In both groups, electrodes were implanted bilaterally into the subthalamic nucleus and into the right pedunculopontine nucleus. Microelectrode recordings were carried out in both groups prior to and during sub thalamic nucleus stimulation. Results: Subthalamic nucleus stimulation produced no clear inhibition of neuronal firing in the pedunculopontine nucleus. However, we found that stimulation of the subthalamic nucleus at 60 Hz produces some entrainment of pedunculopontine nucleus neuronal firing and a shift of subthalamic nucleus firing patterns to more tonic and random patterns. These results are consistent with the effects of deep brain stimulation on neuronal activity in the subthalamic nucleus and globus pallidus internus. Conclusion: The result of this study provides additional evidence to improve our understanding of the mechanism of subthalamic nucleus-deep brain stimulation, and its physiological consequences. (C) 2016 S. Karger AG, Basel

引用

页码：54 / 59

页数：6

共 38 条

[31] Physiological identification of the human pedunculopontine nucleus [J].

Shimamoto, S. A. ;

Larson, P. S. ;

Ostrem, J. L. ;

Glass, G. A. ;

Turner, R. S. ;

Starr, P. A. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (01) :80-86

[32] Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease [J].

Stefani, Alessandro ;

Lozano, Andres M. ;

Peppe, Antonella ;

Stanzione, Paolo ;

Galati, Salvatore ;

Tropepi, Domenicantonio ;

Pierantozzi, Mariangela ;

Brusa, Livia ;

Scarnati, Eugenio ;

Mazzone, Paolo .

BRAIN, 2007, 130 :1596-1607

[33] Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: A new concept for understanding motor disorders in basal ganglia dysfunction [J].

Takakusaki, K ;

Habaguchi, T ;

Ohtinata-Sugimoto, J ;

Saitoh, K ;

Sakamoto, T .

NEUROSCIENCE, 2003, 119 (01) :293-308

[34] Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus [J].

Tattersall, Timothy L. ;

Stratton, Peter G. ;

Coyne, Terry J. ;

Cook, Raymond ;

Silberstein, Paul ;

Silburn, Peter A. ;

Windels, Francois ;

Sah, Pankaj .

NATURE NEUROSCIENCE, 2014, 17 (03) :449-454

[35] The impact of low-frequency stimulation of the pedunculopontine nucleus region on reaction time in parkinsonism [J].

Thevathasan, Wesley ;

Silburn, Peter A. ;

Brooker, Helen ;

Coyne, Terry J. ;

Khan, Sadaquate ;

Gill, Steven S. ;

Aziz, Tipu Z. ;

Brown, Peter .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (10) :1099-1104

[36] Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat [J].

Wang, Hui-Ling ;

Morales, Marisela .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 29 (02) :340-358

[37] Pedunculopontine nucleus microelectrode recordings in movement disorder patients [J].

Weinberger, Moran ;

Hamani, Clement ;

Hutchison, William D. ;

Moro, Elena ;

Lozano, Andres M. ;

Dostrovsky, Jonathan O. .

EXPERIMENTAL BRAIN RESEARCH, 2008, 188 (02) :165-174

[38]

Wichmann T, 2006, J NEURAL TRANSM-SUPP, P21

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