Epicardial fat: a new cardiovascular therapeutic target

被引：67
作者：
Iacobellis, Gianluca [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Med, Div Diabet Endocrinol & Metab, Miami, FL 33136 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2016年 / 27卷
关键词：
TYPE-2; DIABETES-MELLITUS; ADIPOSE-TISSUE; BARIATRIC SURGERY; GLP-1; RECEPTOR; WEIGHT-LOSS; THICKNESS; OBESITY; ASSOCIATION; ATHEROSCLEROSIS; PLASMA;
D O I：
10.1016/j.coph.2016.01.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epicardial fat is the visceral fat depot of the heart. Given its rapid metabolism, organ fat specificity and simple objective measurability, epicardial fat can serve as target for pharmaceutical agents targeting the adipose tissue. Epicardial fat has shown to significantly respond to thiazolidinediones, glucagon like peptide 1 receptor agonists, dipeptidyl peptidase-4 inhibitors and statins. Epicardial fat may represent a measurable risk factor and modifiable therapeutic target. Targeted pharmaceutical interventions may allow the epicardial fat to resume its physiological role. A drug-induced browning effect on epicardial fat suggests the development of pharmacological strategies to increase energy consumption. The potential of modulating the epicardial fat transcriptome with targeted pharmacological agents can open new avenues in the pharmacotherapy of cardio-metabolic diseases.
引用
收藏
页码：13 / 18
页数：6
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