Quantitative structure-activity relationship analyses of antioxidant and free radical scavenging activities for hydroxybenzalacetones

被引：15
作者：
Yamagami, C [1 ]
Motohashi, N
Emoto, T
Hamasaki, A
Tanahashi, T
Nagakura, N
Takeuchi, Y
机构：
[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan
[2] Kanazawa Univ, Fac Sci, Dept Chem, Tuchiya, Kanagawa 2591293, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 22期
关键词：
QSAR; antioxidant activity;
D O I：
10.1016/j.bmcl.2004.08.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antioxidant activities for a series of hydroxybenzalacetones, OH-BZ, were evaluated by measuring inhibitory potencies of OH-BZ against lipid peroxidation induced by t-BuOOH or gamma-irradiation. Their quantitative structure-activity relationship (QSAR) studies indicated that the activities are mainly governed by electronic and steric factors. To rationalize these results, we also performed QSAR analyses for DPPH radical scavenging activities of OH-BZ, which indicated that antioxidant and radical scavenging activities could be expressed by the same physicochemical parameters but the hydrogen bonding behavior of phenolic OH varies with the reaction medium. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5629 / 5633
页数：5
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