Substrains matter in phenotyping of C57BL/6 mice

被引：74

作者：

Mekada, Kazuyuki ^{[1
,2
]}

Yoshiki, Atsushi ^{[2
]}

机构：

[1] Okayama Univ Sci, Dept Zool, Kita Ku, 1-1 Ridai Cho, Okayama 7000005, Japan

[2] RIKEN BioResource Res Ctr, Expt Anim Div, 3-1-1 Koyadai, Tsukuba, Ibaraki 3050074, Japan

来源：

EXPERIMENTAL ANIMALS | 2021年 / 70卷 / 02期

关键词：

C57BL/6; genetic difference; phenotypic difference; single nucleotide polymorphism (SNP); substrain; NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; EMBRYONIC STEM-CELLS; DIET-INDUCED OBESITY; MOUSE STRAINS; NEUROANATOMICAL DIVERGENCE; BEHAVIORAL-DIFFERENCES; SPONTANEOUS MUTATION; ALPHA-SYNUCLEIN; BONE LOSS; GENE;

D O I：

10.1538/expanim.20-0158

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The inbred mouse strain C57BL/6 has been widely used as a background strain for spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged into two major groups in the 1950s, namely, C57BL/6J and C57BL/6N, and more than 20 substrains have been established from them worldwide. We previously reported genetic differences among C57BL/6 substrains in 2009 and 2015. Since then, dozens of reports have been published on phenotypic differences in behavioral, neurological, cardiovascular, and metabolic traits. Substrains need to be chosen according to the purpose of the study because phenotypic differences might affect the experimental results. In this paper, we review recent reports of phenotypic and genetic differences among C57BL/6 substrains, focus our attention on the proper use of C57BL/6 and other inbred strains in the era of genome editing, and provide the life science research community wider knowledge about this subject.

引用

页码：145 / 160

页数：16

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