Species-Specific Inhibition of Foamy Viruses from South American Monkeys by New World Monkey TRIM5α Proteins

被引：39

作者：

Pacheco, Beatriz ^{[1
,2
]}

Finzi, Andres ^{[1
,2
]}

McGee-Estrada, Kathleen ^{[1
,2
]}

Sodroski, Joseph ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Div Aids, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 08期

基金：

美国国家卫生研究院;

关键词：

RETROVIRUS RESTRICTION; OLD-WORLD; INFECTION; DOMAIN;

D O I：

10.1128/JVI.02631-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Foamy virus evolution closely parallels that of the host species, indicating virus-host coadaptation. We studied simian foamy viruses (SFVs) from common marmosets, spider monkeys, and squirrel monkeys, New World monkey (NWM) species that share geographic ranges. The TRIM5 alpha protein from each of these NWM species inhibited the replication of at least one of the SFVs associated with the other two species but did not affect the replication of its own SFV. Thus, TRIM5 alpha has potentially shaped the evolution of SFVs in NWM hosts. Conversely, SFVs may have influenced the evolution of TRIM5 variants in New World primates.

引用

页码：4095 / 4099

页数：5

共 23 条

[1] Identification of Postentry Restrictions to Mason-Pfizer Monkey Virus Infection in New World Monkey Cells [J].