Modulation of Pro-inflammatory and Anti-inflammatory Cytokines in the Fat by an Aloe Gel-based Formula, QDMC, Is Correlated with Altered Gut Microbiota

被引：8

作者：

An, Jinho ^{[1
]}

Lee, Heetae ^{[1
]}

Lee, Sungwon ^{[1
]}

Song, Youngcheon ^{[1
]}

Kim, Jiyeon ^{[2
]}

Park, Il Ho ^{[1
]}

Kong, Hyunseok ^{[2
,3
]}

Kim, Kyungjae ^{[1
]}

机构：

[1] Sahmyook Univ, Coll Pharm, 815,Hwarang Ro, Seoul 01795, South Korea

[2] Sahmyook Univ, Climacter Nat Prod Res Inst, Seoul 01795, South Korea

[3] Sahmyook Univ, Coll Anim Biotechnol & Resource, Seoul 01795, South Korea

来源：

IMMUNE NETWORK | 2021年 / 21卷 / 02期

关键词：

Qmatrix-diabetes-mellitus complex; Gut microbiota; Anti-inflammatory; Proinflammatory; Type; 2; diabetes; INSULIN-RESISTANCE; OBESITY; DIET; HYPERGLYCEMIA; MICE; DEFICIENT;

D O I：

10.4110/in.2021.21.e15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-alpha and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of Bacteroides, Butyricimonas, Ruminococcus, and Mucispirillum were simultaneously significantly increased. The abundance of these bacteria was correlated to the expression levels of cytokines. Our findings suggest that the immunomodulatory activity of QDMC is partly mediated by the altered gut microbiota composition.

引用

页数：10

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