Interpenetrating polymer network as a pioneer drug delivery system: a review

被引:39
作者
Raina, Neha [1 ]
Rani, Radha [1 ]
Khan, Azmi [1 ]
Nagpal, Kalpana [2 ]
Gupta, Madhu [1 ]
机构
[1] Delhi Pharmaceut Sci & Res Univ, Dept Pharmaceut, Sect 3,MB Rd, New Delhi 110017, India
[2] Amity Univ, Amity Inst Pharm, Noida 201303, UP, India
关键词
Interpenetrating polymer network; Controlled release; Drug delivery; Polymer; Biocompatible; SODIUM CARBOXYMETHYL CELLULOSE; TAMARIND SEED POLYSACCHARIDE; CONTROLLED-RELEASE; IN-VITRO; DICLOFENAC SODIUM; KAPPA-CARRAGEENAN; MEDICAL DEVICES; GELLAN GUM; HYDROGELS; CHITOSAN;
D O I
10.1007/s00289-019-02996-5
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Interpenetrating polymer network (IPN) is an enterprising drug delivery system, comprising of two polymers with several advantages like stability, biocompatibility, high swelling capacity and biodegradability which plays an important function in targeted and controlled drug delivery. IPN acquired appreciable focus in the pharmaceutical sector mostly for the last few decades because of their utility in biomedical applications like tissue engineering and drug delivery at the target site at desired rate. For the past few years, different types of polymers obtained from natural or artificial sources have been used to prepare the IPN, resulting in improved properties; thus, IPN is considered in the category of the novel technologies demonstrating the superior performances as compared to the conventional technique. IPN development leads to the formation of dosage form with reduced side effects and prolonged drug action. The current topic includes IPN, types of IPN, mode of preparation, applications, delivery systems and list of polymers employed in the synthesis of IPN.
引用
收藏
页码:5027 / 5050
页数:24
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