Controlling Porosity of Calcium Alginate Hydrogels by Interpenetrating Polyvinyl Alcohol-Diboronate Polymer Network

被引：25

作者：

Roquero, Daniel Massana ^{[1
]}

Bollella, Paolo ^{[1
]}

Katz, Evgeny ^{[1
]}

Melman, Artem ^{[1
]}

机构：

[1] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA

来源：

ACS APPLIED POLYMER MATERIALS | 2021年 / 3卷 / 03期

关键词：

calcium alginate; polyvinyl alcohol; boronate; proteins; encapsulation; drug release;

D O I：

10.1021/acsapm.0c01358

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The high porosity of calcium alginate hydrogels was controlled by its treatment with polyvinyl alcohol followed by cross-linking with diboronic acids, which blocks larger pores in calcium alginate. Low molecular weight (11-31 kDa) polyvinyl alcohol selectively diffuses into larger pores of calcium alginate hydrogels, and the subsequent cross-linking with 1,3-benzenediboronic acid is highly efficient, providing stoichiometry of one 1,3-benzenediboronic acid per four OH groups of polyvinyl alcohol. Cross-linking blocks larger pores in calcium alginate hydrogels, decreasing leaching of model bovine serum albumin, insulin, and myoglobin proteins physically entrapped in calcium alginate hydrogels by 20-30 fold. Internal pore blockage was confirmed by scanning electron microscopy and surface pore closure by liquid atomic force microscopy.

引用

页码：1499 / 1507

页数：9

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