Hematopoietic stem cell transplantation for HIV cure

被引：40

作者：

Kuritzkes, Daniel R. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Infect Dis, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2016年 / 126卷 / 02期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; BONE-MARROW-TRANSPLANTATION; NON-HODGKINS-LYMPHOMA; CD4; T-CELLS; LENTIVIRAL VECTOR; INFECTED PATIENTS; CCR5; RECEPTOR; AIDS; COMBINATION;

D O I：

10.1172/JCI80563

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The apparent cure of an HIV-infected person following hematopoietic stem cell transplantation (HSCT) from an allogeneic donor homozygous for the ccr5 Delta 32 mutation has stimulated the search for strategies to eradicate HIV or to induce long-term remission without requiring ongoing antiretroviral therapy. A variety of approaches, including allogeneic HSCT from CCR5-deficient donors and autologous transplantation of genetically modified hematopoietic stem cells, are currently under investigation. This Review covers the experience with HSCT in HIV infection to date and provides a survey of ongoing work in the field. The challenges of developing HSCT for HIV cure in the context of safe, effective, and convenient once-daily antiretroviral therapy are also discussed.

引用

页码：432 / 437

页数：6

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