Synthesis and Reactions of Some New Thieno[2,3-C]pyridazine Derivatives

被引：3
作者：
Al-Kamali, Ahmed S. N. [1 ]
机构：
[1] Taiz Univ, Fac Sci, Dept Chem, Taizi, Yemen
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 07期
关键词：
Pyridazine; pyridazothienotriazine; pyrimidothienopyridazine; thieno[2,3-c]pyridazine; INHIBITORS;
D O I：
10.1080/10426500802353213
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The alkylation of 4-cyano-5,6-dimethylpyridazin-3(2H)-thione 3 with some halo compounds gave the S-alkylated products 4a-c, which upon treatment with ethanolic sodium ethoxide afforded the cyclized thienopyridazines 5a-c as products. Pyridazothienotriazines 6a-c were prepared by the treatment of compounds 5a-c with nitrous acid, while their reaction with triethyl orthoformate and with carbon disulfide gave the corresponding pyrimidothienopyridazines 7a-c, and 8a-c, respectively. S-alkylated products 9a-o were obtained by the reaction of 8a-c with some halo compounds.
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页码：1812 / 1824
页数：13
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