Oriented Synthesis and In Vitro Anticancer Activity of Biquinazoline-2,2′-diones

被引：14

作者：

Dou, Guolan ^{[1
]}

Shi, Daqing ^{[1
]}

Li, Yonghai ^{[2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Xinxiang Med Univ, Life Sci & Tech Dept, Xinxiang 453003, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 01期

关键词：

LOW-VALENT TITANIUM; QUINAZOLINONE DERIVATIVES; BIOLOGICAL EVALUATION; INHIBITORS; ALDEHYDES; DESIGN; AGENTS; AID;

D O I：

10.1021/cc9001247

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and sonic were found to have good anticancer activity.

引用

页码：195 / 199

页数：5

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