Cerebellum, Language, and Cognition in Autism and Specific Language Impairment

被引：101

作者：

Hodge, Steven M. ^{[1
,2
]}

Makris, Nikos ^{[2
]}

Kennedy, David N. ^{[2
]}

Caviness, Verne S., Jr. ^{[2
]}

Howard, James ^{[2
]}

McGrath, Lauren ^{[3
]}

Steele, Shelly ^{[3
]}

Frazier, Jean A. ^{[4
,5
]}

Tager-Flusberg, Helen ^{[3
]}

Harris, Gordon J. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Radiol Comp Aided Diagnost Lab, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Morphometr Anal, Boston, MA 02114 USA

[3] Boston Univ, Sch Med, Cognit Neurosci Lab, Boston, MA 02118 USA

[4] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[5] Ctr Child & Adolescent Dev, Dept Psychiat, Cambridge, MA USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2010年 / 40卷 / 03期

关键词：

Autism; Specific language impairment; Cerebellum; Broca's area; Asymmetry; CEREBRAL-BLOOD-FLOW; NEUROPSYCHOLOGICAL CONSEQUENCES; CEREBROCEREBELLAR SYSTEM; ASSOCIATION CORTEX; CHILDHOOD AUTISM; INFANTILE-AUTISM; VERBAL FLUENCY; RISK-FACTORS; BROCAS-AREA; BRAIN;

D O I：

10.1007/s10803-009-0872-7

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.

引用

页码：300 / 316

页数：17

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