Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array

被引:17
作者
Fridholm, Helena [1 ]
Sorensen, Line Ostergaard [2 ]
Rosenstierne, Maiken W. [1 ]
Nielsen, Henrik [2 ]
Sellebjerg, Finn [4 ]
Andersen, Ase Bengard [3 ]
Fomsgaard, Anders [1 ,3 ]
机构
[1] Statens Serum Inst, Dept Microbiol Diagnost & Virol, Virus Res & Dev, DK-2300 Copenhagen, Denmark
[2] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark
[3] Univ Southern Denmark, Infect Dis Res Unit, Inst Clin, Copenhagen, Denmark
[4] Univ Copenhagen, Rigshosp, Dept Neurol, DK-2100 Copenhagen, Denmark
关键词
Microarray; HPgV; Metagenomics; Encephalitis; HEPATITIS-G VIRUS; C/HEPATITIS-G VIRUS; SWEDISH BLOOD-DONORS; GBV-C; INFECTION; E2; TRANSMISSION; POPULATION; PREVALENCE; ANTIBODIES;
D O I
10.1016/j.jcv.2016.01.013
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We have used a metagenomic microarray to detect genomic RNA from human pegivirus in serum and cerebrospinal fluid from a patient suffering from severe encephalitis. No other pathogen was detected. HPgV in cerebrospinal fluid during encephalitis has never been reported before and its prevalence in cerebrospinal fluid needs further investigation. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:5 / 8
页数:4
相关论文
共 34 条
[2]   GB virus C: the good boy virus? [J].
Bhattarai, Nirjal ;
Stapleton, Jack T. .
TRENDS IN MICROBIOLOGY, 2012, 20 (03) :124-130
[3]   Hepatitis C virus and GB virus C hepatitis G virus viremia in Swedish blood donors with different alanine aminotransferase levels [J].
Björkman, P ;
Sundström, G ;
Widell, A .
TRANSFUSION, 1998, 38 (04) :378-384
[4]   A case-control study of transmission routes for GB virus C/hepatitis G virus in Swedish blood donors lacking markers for hepatitis C virus infection [J].
Björkman, P ;
Nauclér, A ;
Winqvist, N ;
Mushahwar, I ;
Widell, A .
VOX SANGUINIS, 2001, 81 (03) :148-153
[5]  
Björkman P, 2001, SCAND J INFECT DIS, V33, P611, DOI 10.1080/00365540110026755
[6]  
Bourlet T, 1999, J MED VIROL, V58, P373, DOI 10.1002/(SICI)1096-9071(199908)58:4<373::AID-JMV9>3.0.CO
[7]  
2-1
[8]   GB virus C epidemiology in Denmark: Different routes of transmission in children and low- and high-risk adults [J].
Christensen, PB ;
Fisker, N ;
Mygind, LH ;
Krarup, HB ;
Wedderkopp, N ;
Varming, K ;
Georgsen, J .
JOURNAL OF MEDICAL VIROLOGY, 2003, 70 (01) :156-162
[9]   Multiplex real-time PCR for the detection and quantification of latent and persistent viral genomes in cellular or plasma blood fractions [J].
Compston, Lara Isobel ;
Sarkobie, Francis ;
Li, Chengyao ;
Candotti, Daniel ;
Opare-Sem, Ohene ;
Allain, Jean-Pierre .
JOURNAL OF VIROLOGICAL METHODS, 2008, 151 (01) :47-54
[10]   A microbial detection array (MDA) for viral and bacterial detection [J].
Gardner, Shea N. ;
Jaing, Crystal J. ;
McLoughlin, Kevin S. ;
Slezak, Tom R. .
BMC GENOMICS, 2010, 11