Determination of Promethazine in Pharmaceutical Samples by Using Graphene Modified Electrode

被引：0

作者：

Chen, Le ^{[1
]}

Wu, Fanghui ^{[1
]}

Chen, Lichun ^{[1
]}

Mei, Jie ^{[1
]}

Wei, Xianwen ^{[1
]}

机构：

[1] Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243002, Anhui Province, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Graphene; Promethazine; Modified electrode; Measurement; GLASSY-CARBON ELECTRODE; SOLID-PHASE EXTRACTION; ELECTROCHEMICAL DETERMINATION; PASTE ELECTRODE; HYDROCHLORIDE; CHROMATOGRAPHY; BEHAVIOR; URINE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A glass carbon electrode modified with functionalized graphene has been fabricated due to its elusive two-dimentional structure and unique electronic properties. Electrochemical experiments indicated the modified electrode showed a preferable electrocatalytic activity for the oxidation of promethazine. Under the optimum conditions, the increase of response current is proportional to the promethazine concentration in the range of 2.0 x 10(-6) and 1.0 x 10(-3) M, with the detection limit of 4.2 x 10(-7) M. In addition, the developed sensor shows acceptable stability and reproducibility. These results demonstrate the viability of the use of graphene modified electrode as a potential amperometric sensor for pharmaceutical and clinical measurements.

引用

页码：3171 / 3174

页数：4

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