Stromal fibroblasts in cancer initiation and progression

被引：1816
作者：
Bhowmick, NA
Neilson, EG
Moses, HL
机构：
[1] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Urol Surg, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
[4] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA
来源：
NATURE | 2004年 / 432卷 / 7015期
关键词：
D O I：
10.1038/nature03096
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
It is widely accepted that the development of carcinoma - the most common form of human cancer - is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.
引用
收藏
页码：332 / 337
页数：6
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