Design of a simulated moving bed: Optimal particle size of the stationary phase

被引：27
作者：
Ludemann-Hombourger, O
Bailly, M
Nicoud, RM
机构：
[1] NOVASEP, F-5450 Vandoeuvre Nancy, France
[2] Lab Sci Genie Chim, F-54001 Nancy, France
来源：
SEPARATION SCIENCE AND TECHNOLOGY | 2000年 / 35卷 / 09期
关键词：
D O I：
10.1081/SS-100100225
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The influence of the particle size on simulated moving bed (SMB) design is studied using the chiral separation of methyl mandelate on Chiralcel OD, The theoretical model of the pressure drop and band dispersion is validated with experimental results obtained with two different particle sizes (20 and 50 mu m) using linear adsorption isotherms. The influence of the particle size on the SMB column size and productivity shows that the optimum particle size is 20-25 mu m when working with an acceptable column length and a minimum amount of stationary phase. Due to the high cost of the coated silica stationary phases used for chiral separation, the separation cost is thus minimized.
引用
收藏
页码：1285 / 1305
页数：21
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