Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality?

被引：55

作者：

Blanc, F. ^{[1
,2
,3
,4
,5
,6
]}

Ruppert, E. ^{[1
,2
,3
]}

Kleitz, C. ^{[1
,2
,3
,6
]}

Valenti, M. P. ^{[1
,2
,3
]}

Cretin, B. ^{[1
,2
,3
,6
]}

Humbel, R. L. ^{[7
]}

Honnorat, J. ^{[8
]}

Namer, I. J. ^{[4
,5
,9
]}

Hirsch, E. ^{[1
,2
,3
,4
,5
]}

Manning, L. ^{[4
,5
]}

de Seze, J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Hosp Strasbourg, Dept Neurol, Serv Neuropsychol, F-67091 Strasbourg, France

[2] Univ Hosp Strasbourg, Dept Neurol, Serv Neurol, F-67091 Strasbourg, France

[3] Univ Hosp Strasbourg, Dept Neurol, Serv Epileptol, F-67091 Strasbourg, France

[4] Strasbourg Univ, LINC, UMR 7191, Strasbourg, France

[5] CNRS, Strasbourg, France

[6] Univ Hosp Strasbourg, Dept Neurol, CMRR Alsace Memory Resource & Res Ctr, Strasbourg, France

[7] Immunopathol Lab, Esch Sur Alzette, France

[8] Neurol Hosp, Dept Neurol, Lyon, France

[9] Univ Hosp Strasbourg, Nucl Med Serv, F-67091 Strasbourg, France

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 287卷 / 1-2期

关键词：

Limbic encephalitis; Autoantibodies; Glutamic acid decarboxylase; GAD65; Autoimmunity; ANTI-GAD ANTIBODY; NEUROLOGICAL SYNDROMES; AUTOANTIBODIES; ASSOCIATION; CELLS;

D O I：

10.1016/j.jns.2009.09.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limbic encephalitis (LE) associated with glutamic acid decarboxylase antibodies (GAD-Ab) is rare. We describe a 30-year-old male with acute LE and GAD-Ab, with follow-up during 2 years of cognitive status including verbal episodic memory, number of seizures recorded by high-resolution video-EEG, brain MRI, 2-[18F]-fluoro-2-deoxyglucose PET and GAD-Ab titres. Treatment with corticosteroids, IV immunoglobulins, immunosuppressors and antiepileptic drugs resulted in improved memory status, disappearance of seizures and decreased GAD-Ab titres. Review of the other cases of literature and this case is in favour of the existence of autoimmune LE associated with GAD-Ab and supports the link between memory, temporal seizures and possibly GAD-Ab titres. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.

引用

页码：69 / 71

页数：3

共 19 条

[1] Limbic encephalitis associated with anti-GAD antibody and common variable immune deficiency [J].