Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing

被引：283
作者：
Giocomo, Lisa M.
Zilli, Eric A.
Fransen, Erik
Hasselmo, Michael E.
机构：
[1] Boston Univ, Dept Psychol, Ctr Memory & Brain, Program Neurosci, Boston, MA 02215 USA
[2] Royal Inst Technol, Sch Comp Sci & Commun, SE-10044 Stockholm, Sweden
[3] Stockholm Brain Inst, SE-10044 Stockholm, Sweden
来源：
SCIENCE | 2007年 / 315卷 / 5819期
关键词：
CORTEX LAYER-II; HEAD DIRECTION CELLS; PATH-INTEGRATION; PLACE CELLS; NEURONS; MODEL; REPRESENTATION; HIPPOCAMPUS; MECHANISMS; DYNAMICS;
D O I：
10.1126/science.1139207
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons in more dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.
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页码：1719 / 1722
页数：4
相关论文
共 28 条
[1]   Synchronization of strongly coupled excitatory neurons: Relating network behavior to biophysics [J].
Acker, CD ;
Kopell, N ;
White, JA .
JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2003, 15 (01) :71-90
[2]   SUBTHRESHOLD NA+-DEPENDENT THETA-LIKE RHYTHMICITY IN STELLATE CELLS OF ENTORHINAL CORTEX LAYER-II [J].
ALONSO, A ;
LLINAS, RR .
NATURE, 1989, 342 (6246) :175-177
[3]  
BLAIR HT, IN PRESS J NEUROSCI
[4]  
BURGESS N, IN PRESS HIPPOCAMPUS
[5]   Properties and role of Ih in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons [J].
Dickson, CT ;
Magistretti, J ;
Shalinsky, MH ;
Fransén, E ;
Hasselmo, ME ;
Alonso, A .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (05) :2562-2579
[6]  
Eichenbaum H., 2003, CONDITIONING CONSCIO
[7]   Dynamics of rat entorhinal cortex layer II and III cells: characteristics of membrane potential resonance at rest predict oscillation properties near threshold [J].
Erchova, I ;
Kreck, G ;
Heinemann, U ;
Herz, AVM .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 560 (01) :89-110
[8]   Mechanism of graded persistent cellular activity of entorhinal cortex layer V neurons [J].
Fransén, E ;
Tahvildari, B ;
Egorov, AV ;
Hasselmo, ME ;
Alonso, AA .
NEURON, 2006, 49 (05) :735-746
[9]   Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neurons [J].
Fransén, E ;
Alonso, AA ;
Dickson, CT ;
Magistretti, J ;
Hasselmo, ME .
HIPPOCAMPUS, 2004, 14 (03) :368-384
[10]   A spin glass model of path integration in rat medial entorhinal cortex [J].
Fuhs, MC ;
Touretzky, DS .
JOURNAL OF NEUROSCIENCE, 2006, 26 (16) :4266-4276
123