Microbial Cell Factories for Green Production of Vitamins

被引:38
|
作者
Wang, Yanyan [1 ,2 ,3 ]
Liu, Linxia [2 ,3 ,4 ]
Jin, Zhaoxia [1 ]
Zhang, Dawei [2 ,3 ,4 ,5 ]
机构
[1] Dalian Polytech Univ, Sch Biol Engn, Dalian, Peoples R China
[2] Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China
[3] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China
[4] Natl Technol Innovat Ctr Synthet Biol, Tianjin, Peoples R China
[5] Univ Chinese Acad Sci, Beijing, Peoples R China
来源
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2021年 / 9卷
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
vitamins; metabolic engineering; microbial cell factory; chemical synthesis; biosynthesis; ALPHA-TOCOPHEROL PRODUCTION; D-ARABINOSE DEHYDROGENASE; L-ASCORBIC-ACID; BACILLUS-SUBTILIS; FOLIC-ACID; S-ADENOSYLMETHIONINE; ESCHERICHIA-COLI; EUGLENA-GRACILIS; BETA-CAROTENE; BIOSYNTHESIS;
D O I
10.3389/fbioe.2021.661562
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Vitamins are a group of essential nutrients that are necessary to maintain normal metabolic activities and optimal health. There are wide applications of different vitamins in food, cosmetics, feed, medicine, and other areas. The increase in the global demand for vitamins has inspired great interest in novel production strategies. Chemical synthesis methods often require high temperatures or pressurized reactors and use non-renewable chemicals or toxic solvents that cause product safety concerns, pollution, and hazardous waste. Microbial cell factories for the production of vitamins are green and sustainable from both environmental and economic standpoints. In this review, we summarized the vitamins which can potentially be produced using microbial cell factories or are already being produced in commercial fermentation processes. They include water-soluble vitamins (vitamin B complex and vitamin C) as well as fat-soluble vitamins (vitamin A/D/E and vitamin K). Furthermore, metabolic engineering is discussed to provide a reference for the construction of microbial cell factories. We also highlight the current state and problems encountered in the fermentative production of vitamins.
引用
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页数:15
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