Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection

被引：13

作者：

Chen, Zhuo ^{[1
,2
]}

Zhang, Yaxin ^{[1
,2
,3
]}

Wang, Dong ^{[1
,2
,3
]}

Li, Linsen ^{[4
]}

Zhou, Shanyong ^{[1
]}

Huang, Joy H. ^{[1
]}

Chen, Jincan ^{[1
]}

Hu, Ping ^{[1
]}

Huang, Mingdong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, 155 West Yangqiao Rd, Fuzhou 350002, Fujian, Peoples R China

[2] Chinese Acad Sci, Grad Univ, 19 Yuquan Rd, Beijing 100049, Peoples R China

[3] Fujian Normal Univ, 1 Keji Rd, Fuzhou 350117, Fujian, Peoples R China

[4] Shenyang Med Coll, 146 North Huanghe Main St, Shenyang 110034, Liaoning, Peoples R China

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2016年 / 21卷 / 01期

关键词：

photodynamic antimicrobial chemotherapy; zinc phthalocyanine; bacterial infection; skin; Propionibacterium acnes; Staphylococcus aureus; THERAPY; STRAINS;

D O I：

10.1117/1.JBO.21.1.018001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine beta-carbonylphthalocyanine zinc (ZnPc-(Lys)(5)). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)(5) showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)(5) was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：7

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