A prospective evaluation of plasma polyphenol levels and colon cancer risk

被引：35

作者：

Murphy, Neil ^{[1
]}

Achaintre, David ^{[1
]}

Zamora-Ros, Raul ^{[2
]}

Jenab, Mazda ^{[1
]}

Boutron-Ruault, Marie-Christine ^{[3
]}

Carbonnel, Franck ^{[3
,4
,5
]}

Savoye, Isabelle ^{[3
,6
]}

Kaaks, Rudolf ^{[7
]}

Kuehn, Tilman ^{[7
]}

Boeing, Heiner ^{[8
]}

Aleksandrova, Krasimira ^{[9
]}

Tjonneland, Anne ^{[10
]}

Kyro, Cecilie ^{[10
]}

Overvad, Kim ^{[11
]}

Quiros, J. Ramon ^{[12
]}

Sanchez, Maria-Jose ^{[13
,14
]}

Altzibar, Jone M. ^{[14
,15
]}

Maria Huerta, Jose ^{[14
,16
]}

Barricarte, Aurelio ^{[14
,17
,18
]}

Khaw, Kay-Tee ^{[19
]}

Bradbury, Kathryn E. ^{[20
]}

Perez-Cornago, Aurora ^{[20
]}

Trichopoulou, Antonia ^{[21
]}

Karakatsani, Anna ^{[21
,22
]}

Peppa, Eleni ^{[21
]}

Palli, Domenico ^{[23
]}

Grioni, Sara ^{[24
]}

Tumino, Rosario ^{[25
]}

Sacerdote, Carlotta ^{[26
,27
]}

Panico, Salvatore ^{[28
]}

Bueno-de-Mesquita, H. B. ^{[29
,30
,31
,32
]}

Peeters, Petra H. ^{[33
,34
]}

Rutegard, Martin ^{[35
]}

Johansson, Ingegerd ^{[36
]}

Freisling, Heinz ^{[1
]}

Noh, Hwayoung ^{[1
]}

Cross, Amanda J. ^{[31
]}

Vineis, Paolo ^{[34
]}

Tsilidis, Kostas ^{[31
,37
]}

Gunter, Marc J. ^{[1
]}

Scalbert, Augustin ^{[1
]}

机构：

[1] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

[2] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain

[3] Univ Paris Saclay, Univ Paris Sud, INSERM, U1018,CESP,UVSQ, Villejuif, France

[4] Univ Paris Sud, Le Kremlin Bicetre, France

[5] Hop Univ Paris Sud, AP HP, CHU Bicetre, Le Kremlin Bicetre, France

[6] Espace Maurice Tubiana, Gustave Roussy, Villejuif, France

[7] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[8] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[9] Start Lab, Dept Epidemiol Nutr Immun & Metab, Potsdam, Germany

[10] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[11] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[12] Publ Hlth Directorate, Asturias, Spain

[13] Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain

[14] CIBER Epidemiol & Salud Publ CIBERES, Madrid, Spain

[15] Breast Canc Screening Program, Osakidetza Basque Hlth Serv, Bilbao, Spain

[16] Murcia Reg Hlth Council, IMIB Arrixaca, Dept Epidemiol, Murcia, Spain

[17] Navarra Publ Hlth Inst, Pamplona, Spain

[18] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[19] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[20] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[21] Hellen Hlth Fdn, Athens, Greece

[22] Univ Athens, ATTIKON Univ Hosp, Sch Med, Pulm Med Dept, Haidari, Greece

[23] Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[24] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[25] Civ MP Arezzo Hosp, ASP Ragusa, Canc Registry & Histopathol Dept, Ragusa, Italy

[26] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[27] Ctr Canc Prevent CPO, Turin, Italy

[28] Univ Naples Federico II, Dipartimento Med Clin & Sperimentale, Naples, Italy

[29] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, NL-3720 BA Bilthoven, Netherlands

[30] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[31] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[32] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia

[33] Univ Med Ctr Utrecht, Dept Epidemiol, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[34] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England

[35] Umea Univ, Dept Surg & Perioperat Sci, Umea degrees, Umea, Sweden

[36] Umea Univ, Dept Odontol, Umea, Sweden

[37] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece

来源：

INTERNATIONAL JOURNAL OF CANCER | 2018年 / 143卷 / 07期

基金：

英国医学研究理事会; 欧洲研究理事会; 瑞典研究理事会;

关键词：

colon cancer; polyphenols; biomarkers; EPIC; nested case-control study; ESTROGEN-RECEPTOR-BETA; COLORECTAL-CANCER; SYSTEMATIC ANALYSIS; FLAVONOID INTAKE; PROSTATE-CANCER; EQUOL; ISOFLAVONES; BREAST; PHYTOESTROGENS; METABOLOME;

D O I：

10.1002/ijc.31563

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q(values)) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log(2)-transformed multivariable models, equol (odds ratio [OR] per log(2)-value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; q(value) = 0.01) and homovanillic acid (OR per log(2)-value, 1.46, 95% CI = 1.16-1.84; q(value) = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, p(trend) = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, p(trend)<0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.

引用

页码：1620 / 1631

页数：12

共 47 条

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