Synthesis of 2-alkyl triazoles with solvothermal conditions

被引：2

作者：

Ma, Youcai ^{[1
]}

Zhang, Xiaohui ^{[1
]}

Yang, Yawen ^{[1
]}

Hu, Liangzhen ^{[1
]}

Xiong, Yan ^{[1
,2
,3
,4
]}

机构：

[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing Key Lab Theoret & Computat Chem, Chongqing 401331, Peoples R China

[2] Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

[3] Xinjiang Inst Engn, Collaborat Innovat Ctr High Value Transformat Coal, Sch Chem & Environm Engn, Urumqi 830091, Xinjiang, Peoples R China

[4] Chongqing Univ, Sch Chem & Chem Engn, Chongqing Key Lab Theoret & Computat Chem, Chongqing 401331, Peoples R China

来源：

TETRAHEDRON | 2022年 / 113卷

关键词：

2-Alkyl triazoles; Metal-free; Nucleophilic substitution; Potassium carbonate; 3-Triazoles; N-ALKYLATION; BENZOTRIAZOLE; 1,2,3-TRIAZOLES; EFFICIENT; AMINATION; ANALOGS; AZIDES;

D O I：

10.1016/j.tet.2022.132765

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general protocol for the straightforward access to 2-alkyl triazoles with alkyl halides as the readily available alkylation reagents, by using a well-organized nucleophilic substitution strategy under metal free and solvothermal conditions has been developed. Various alkyl substitutions on 2-site of triazoles occurred and were mainly examined in the text. Particularly, the reactions between linear bisbromo alkanes and 1,2,3-triazoles were executed to yield bromoalkyl triazoles and bistriazoles, and realkylations of bromoalkyl triazoles were achieved through addition of triazoles. This procedure is convenient and generally affords the 2-alkylated products, which are slightly scarce under present synthetic methodologies. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：8

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