Stem cell-derived organoids and their application for medical research and patient treatment

被引：155

作者：

Bartfeld, Sina ^{[1
]}

Clevers, Hans ^{[2
,3
]}

机构：

[1] Univ Wurzburg, Inst Mol Infect Biol, Res Ctr Infect Dis, ZINF,IMIB, Josef SchneiderStr 2-D15, D-97080 Wurzburg, Germany

[2] Hubrecht Inst, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands

[3] Princess Maxima Ctr Pediat Oncol, NL-3584 CT Utrecht, Netherlands

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 07期

关键词：

Organoid; Stem cell; CFTR; Cancer; Infectious disease; Personalized medicine; Disease modelling; IN-VITRO EXPANSION; DUCTAL PANCREATIC-CANCER; DIRECTED DIFFERENTIATION; COLORECTAL-CANCER; HUMAN COLON; 3-DIMENSIONAL CULTURE; INTESTINAL ORGANOIDS; EPITHELIAL-CELLS; SELF-FORMATION; SINGLE LGR5;

D O I：

10.1007/s00109-017-1531-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

3D culture has allowed the initiation and expansion of organ-like structures, called organoids, from either tissue-resident adult stem cells or pluripotent stem cells. Today, organoids can be grown to resemble a wide variety of organs, exhibiting remarkable similarity to their in vivo counterparts. As successful organoid generation is possible from virtually every patient, organoids hold a great promise for medical research and the development of new treatments. They have already found their way into the clinic, enabling personalized medicine in small patient trials. In this review, we provide an update on current organoid technology and summarize their application in basic research, disease modelling, drug development, personalized treatment and regenerative medicine.

引用

页码：729 / 738

页数：10

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