Evolving concepts of tumor heterogeneity

被引：54

作者：

Zellmer, Victoria R. ^{[1
]}

Zhang, Siyuan ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Biol Sci, Harper Canc Res Inst, Notre Dame, IN 46556 USA

来源：

CELL AND BIOSCIENCE | 2014年 / 4卷

关键词：

Tumor heterogeneity; Tumor evolution; Tumor microenvironment; Cancer stem cell; Omic analysis and personalized therapy; CANCER STEM-CELLS; BREAST-CANCER; MUTATIONAL PROCESSES; MUTATOR PHENOTYPE; CLONAL EVOLUTION; GENOME; LEUKEMIA; MICROENVIRONMENT; IDENTIFICATION; INFLAMMATION;

D O I：

10.1186/2045-3701-4-69

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Past and recent findings on tumor heterogeneity have led clinicians and researchers to broadly define cancer development as an evolving process. This evolutionary model of tumorigenesis has largely been shaped by seminal reports of fitness-promoting mutations conferring a malignant cellular phenotype. Despite the major clinical and intellectual advances that have resulted from studying heritable heterogeneity, it has long been overlooked that compositional tumor heterogeneity and tumor microenvironment (TME)-induced selection pressures drive tumor evolution, significantly contributing to tumor development and outcomes of clinical cancer treatment. In this review, we seek to summarize major milestones in tumor evolution, identify key aspects of tumor heterogeneity in a TME-dependent evolutionary context, and provide insights on the clinical challenges facing researchers and clinicians alike.

引用

页数：8

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