Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls

被引：93

作者：

Biselli, R. ^{[2
]}

Mariotti, S.

Sargentini, V.

Sauzullo, I. ^{[3
]}

Lastilla, M. ^{[2
]}

Mengoni, F. ^{[3
]}

Vanini, V. ^{[4
]}

Girardi, E. ^{[4
]}

Goletti, D. ^{[4
]}

D' Amelio, R. ^{[3
,5
]}

Nisini, R. ^{[1
]}

机构：

[1] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, I-00161 Rome, Italy

[2] Serv Sanit, Rome, Italy

[3] Sapienza Univ Roma, Rome, Italy

[4] Ist Nazl Malattie Infett L Spallanzani, Rome, Italy

[5] Minist Difesa, Direz Gen Sanita Mil, Rome, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 08期

关键词：

Diagnosis; IFN-gamma; IL-2; latent infection; tuberculosis; T-CELLS; IFN-GAMMA; DIAGNOSIS; ASSAYS;

D O I：

10.1111/j.1469-0691.2009.03104.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

P>Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-gamma and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-gamma distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.

引用

页码：1282 / 1284

页数：3

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