Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls

被引：92
作者：
Biselli, R. [2 ]
Mariotti, S.
Sargentini, V.
Sauzullo, I. [3 ]
Lastilla, M. [2 ]
Mengoni, F. [3 ]
Vanini, V. [4 ]
Girardi, E. [4 ]
Goletti, D. [4 ]
D' Amelio, R. [3 ,5 ]
Nisini, R. [1 ]
机构：
[1] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, I-00161 Rome, Italy
[2] Serv Sanit, Rome, Italy
[3] Sapienza Univ Roma, Rome, Italy
[4] Ist Nazl Malattie Infett L Spallanzani, Rome, Italy
[5] Minist Difesa, Direz Gen Sanita Mil, Rome, Italy
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 08期
关键词：
Diagnosis; IFN-gamma; IL-2; latent infection; tuberculosis; T-CELLS; IFN-GAMMA; DIAGNOSIS; ASSAYS;
D O I：
10.1111/j.1469-0691.2009.03104.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
P>Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-gamma and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-gamma distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.
引用
收藏
页码：1282 / 1284
页数：3
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