Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization

被引:1158
作者
Putnam, Nicholas H.
Srivastava, Mansi
Hellsten, Uffe
Dirks, Bill
Chapman, Jarrod
Salamov, Asaf
Terry, Astrid
Shapiro, Harris
Lindquist, Erika
Kapitonov, Vladimir V.
Jurka, Jerzy
Genikhovich, Grigory
Grigoriev, Igor V.
Lucas, Susan M.
Steele, Robert E.
Finnerty, John R.
Technau, Ulrich
Martindale, Mark Q.
Rokhsar, Daniel S. [1 ]
机构
[1] Dept Energy Joint Genome Inst, Walnut Creek, CA 94598 USA
[2] Univ Calif Berkeley, Ctr Integrat Genom, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[4] Genet Informat Res Inst, Mountain View, CA 94043 USA
[5] Univ Bergen, Sars Int Ctr Marine Mol Biol, N-5008 Bergen, Norway
[6] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA
[7] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA
[8] Boston Univ, Dept Biol, Boston, MA 02215 USA
[9] Univ Hawaii, Kewalo Marine Lab, Honolulu, HI 96813 USA
关键词
RELAXED MOLECULAR CLOCK; NEMATOSTELLA-VECTENSIS; EVOLUTION; EXPRESSION; ORIGINS; CNIDARIA; HOX; COMPLEXITY; JELLYFISH; DIVERSIFICATION;
D O I
10.1126/science.1139158
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sea anemones are seemingly primitive animals that, along with corals, jellyfish, and hydras, constitute the oldest eumetazoan phylum, the Cnidaria. Here, we report a comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis. The sea anemone genome is complex, with a gene repertoire, exon-intron structure, and large-scale gene linkage more similar to vertebrates than to flies or nematodes, implying that the genome of the eumetazoan ancestor was similarly complex. Nearly one-fifth of the inferred genes of the ancestor are eumetazoan novelties, which are enriched for animal functions like cell signaling, adhesion, and synaptic transmission. Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.
引用
收藏
页码:86 / 94
页数:9
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