The impact of autophagy on peripheral synapses in health and disease

被引：7

作者：

Rudolf, Rudiger ^{[1
,2
,3
]}

Khan, Muzamil Majid ^{[1
,2
,3
]}

Wild, Franziska ^{[1
,2
,3
]}

Hashemolhosseini, Said ^{[4
]}

机构：

[1] Mannheim Univ Appl Sci, Inst Mol & Cell Biol, Paul Wittsack Strabe 10, D-68163 Mannheim, Germany

[2] Heidelberg Univ, Interdisciplinary Ctr Neurosci, Neuenheimer Feld 364, D-69120 Heidelberg, Germany

[3] Karlsruhe Inst Technol, Inst Toxicol & Genet, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[4] Univ Erlangen Nurnberg, Inst Biochem, Fahrstrabe 17, D-91054 Erlangen, Germany

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2016年 / 21卷

关键词：

Review; NMJ; Autophagy; Peripheral Nervous System; Aggresome; Mitophagy; TERMINAL AGRIN FRAGMENT; SKELETAL-MUSCLE ATROPHY; E3 UBIQUITIN LIGASE; VALOSIN-CONTAINING PROTEIN; SLOW AXONAL-TRANSPORT; JUNCTION IN-VIVO; NEUROMUSCULAR-JUNCTION; ACETYLCHOLINE-RECEPTORS; SELECTIVE AUTOPHAGY; AMPA RECEPTORS;

D O I：

10.2741/4467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations of autophagy have been linked to several peripheral nervous system diseases, such as amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease. Modulation of autophagy by metabolic or pharmacological interventions has been increasingly recognized as a strategy to fight many of these disorders. Cellular processes that are aberrant in case of impaired autophagy and that might lead to these diseases belong to three different categories: (1) clearing of protein aggregates, (2) regulation of vesicle and cargo turnover, and (3) disposal of damaged mitochondria. This review summarizes the present literature that addresses both, the impact and mechanisms of autophagy on the health of the peripheral nervous system and treatment proposals for human disorders associated with impaired autophagy.

引用

页码：1474 / 1487

页数：14

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