The potential of dendrimer in delivery of therapeutics for dentistry

被引：34

作者：

Bapat, Ranjeet A. ^{[1
]}

Dharmadhikari, Suyog ^{[2
]}

Chaubal, Tanay, V ^{[1
]}

Amin, Mohd Cairul Iqbal Mohd ^{[3
]}

Bapat, Prachi ^{[4
]}

Gorain, Bapi ^{[5
]}

Choudhury, Hira ^{[6
]}

Vincent, Christopher ^{[7
]}

Kesharwani, Prashant ^{[8
]}

机构：

[1] Int Med Univ, Sch Dent, Div Clin Dent, Kuala Lumpur 57000, Malaysia

[2] DY Patil Univ, Sch Dent, Navi Mumbai 400706, India

[3] Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Res, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

[4] Modern Dent Coll, Indore 453112, Madhya Pradesh, India

[5] Taylors Univ, Fac Hlth & Med Sci, Sch Pharm, Subang Jaya 47500, Selangor, Malaysia

[6] Int Med Univ, Sch Pharm, Dept Pharmaceut Technol, Kuala Lumpur 57000, Malaysia

[7] Int Med Univ, Sch Dent, Div Oral Diagnost & Surg Sci, Kuala Lumpur 57000, Malaysia

[8] Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

来源：

HELIYON | 2019年 / 5卷 / 10期

关键词：

Dentistry; Materials science; Dental plaque; Antimicrobial; Dendrimers; Adhesives; Biomimetic; Periodontal; POLY(AMIDOAMINE) PAMAM DENDRIMERS; SYSTEMIC AMOXICILLIN/METRONIDAZOLE; POLYAMIDOAMINE DENDRIMER; ADJUNCTIVE THERAPY; DRUG-DELIVERY; NITRIC-OXIDE; IN-VITRO; REMINERALIZATION; PLAQUE; NANOPARTICLES;

D O I：

10.1016/j.heliyon.2019.e02544

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dendrimers are hyperbranched nanoparticle structures along with its surface modifications can to be used in dental biomaterials for biomimetic remineralisation of enamel and dentin. The review highlights the therapeutic applications of dendrimers in the field of dentistry. It addresses the possible mechanisms of enhancement of mechanical properties of adhesives and resins structure. Dendrimers due to its unique construction of possessing inner hydrophobic and outer hydrophilic structure can act as drug carrier for delivery of antimicrobial drugs for treatment of periodontal diseases and at peripheral dental implant areas. Dendrimers due to its hyperbranched structures can provides a unique drug delivery vehicle for delivery of a drug at specific site for sustained release for therapeutic effects. Thus, dendrimers can be one of the most important constituents which can be incorporated in dental biomaterials for better outcomes in dentistry.

引用

页数：15

共 113 条

[31] Systemic antibiotics in the treatment of periodontitis [J].

Feres, Magda ;

Figueiredo, Luciene C. ;

Soares, Geisla M. Silva ;

Faveri, Marcelo .

PERIODONTOLOGY 2000, 2015, 67 (01) :131-186

[32]

Frechet J.M, 2001, Dendrimers and Other Dendritic Polymers

[33] Biomimetic coating with phosphoserine-tethered poly(epsilon-lysine) dendrons on titanium surfaces enhances Wnt and osteoblastic differentiation [J].

Galli, Carlo ;

Piemontese, Marilina ;

Meikle, Steven T. ;

Santin, Matteo ;

Macaluso, Guido M. ;

Passeri, Giovanni .

CLINICAL ORAL IMPLANTS RESEARCH, 2014, 25 (02) :E133-E139

[34] Effect and Stability of Poly(Amido Amine)-Induced Biomineralization on Dentinal Tubule Occlusion [J].

Gao, Yuan ;

Liang, Kunneng ;

Li, Jianshu ;

Yuan, He ;

Liu, Hongling ;

Duan, Xiaolei ;

Li, Jiyao .

MATERIALS, 2017, 10 (04)

[35] PAMAM dendrimers for the delivery of the antibacterial Triclosan [J].

Gardiner, Jonathan ;

Freeman, Sally ;

Leach, Matthew ;

Green, Alison ;

Alcock, Jacqui ;

D'Emanuele, Antony .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2008, 23 (05) :623-628

[36] Novel Dental Adhesive with Biofilm-Regulating and Remineralization Capabilities [J].

Ge, Yang ;

Ren, Biao ;

Zhou, Xuedong ;

Xu, Hockin H. K. ;

Wang, Suping ;

Li, Mingyun ;

Weir, Michael D. ;

Feng, Mingye ;

Cheng, Lei .

MATERIALS, 2017, 10 (01)

[37] ACIDS PRODUCED BY HUMAN DENTAL PLAQUE METABOLISM INSITU [J].

GEDDES, DAM .

CARIES RESEARCH, 1975, 9 (02) :98-109

[38] Dendrimers and dendritic polymers in drug delivery [J].

Gillies, ER ;

Fréchet, JMJ .

DRUG DISCOVERY TODAY, 2005, 10 (01) :35-43

[39]

Gorain B., 2018, MAT SCI ENG C

[40]

Gorain B., 2019, DRUG DELIV SYST LUNG, P39, DOI DOI 10.1016/B978-0-12-815720-6.00003-4

← 1 2 3 4 5 6 7 8 9 10 →