Microbiome in cancer: An exploration of carcinogenesis, immune responses and immunotherapy

被引：14

作者：

Zhou, Pei ^{[1
,2
]}

Hu, Yawen ^{[1
,2
]}

Wang, Xiaoyan ^{[1
,2
]}

Shen, Luxuan ^{[3
]}

Liao, Xinghao ^{[4
]}

Zhu, Yajuan ^{[5
,6
]}

Yu, Jiadong ^{[1
,2
]}

Zhao, Fulei ^{[1
,2
]}

Zhou, Yi ^{[4
]}

Shen, Hengshui ^{[7
]}

Li, Jiong ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, West China Med Sch,State Key Lab Biotherapy, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Canc Ctr, Collaborat Innovat Ctr Biotherapy,West China Med S, Chengdu, Peoples R China

[3] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu, Peoples R China

[4] Chengdu Seventh Peoples Hosp, Dept Med Examinat, Chengdu, Peoples R China

[5] Sichuan Univ, West China Hosp, Dept Biotherapy, State Key Lab Biotherapy, Chengdu, Peoples R China

[6] Sichuan Univ, West China Hosp, Canc Ctr, State Key Lab Biotherapy, Chengdu, Peoples R China

[7] Sichuan Aupone Pharmaceut Co Ltd, Chengdu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

oncomicrobes; microbiota disorders; gut microbiota; immune cells; cancer immunotherapy; metabolism; HELICOBACTER-PYLORI INFECTION; ORAL EPITHELIAL-CELLS; HUMAN GUT MICROBIOME; FUSOBACTERIUM-NUCLEATUM; COMMENSAL BACTERIA; COLORECTAL-CANCER; PROSTATE-CANCER; TUMOR-GROWTH; MECHANISMS; TRANSPLANTATION;

D O I：

10.3389/fimmu.2022.877939

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer is a major disease endangering human health. More and more studies have shown that microorganisms play an extremely important role in the occurrence, development and treatment of tumors. As a very promising tumor treatment strategy, immunotherapy has also been proved to have a great relationship with microorganisms. Here, the authors review the contribution of the microbiota to cancer and the research on its impact on cancer immunotherapy. We also highlight the possible mechanism of their interaction and outlined the potential application of microbiota in tumor immunotherapy.

引用

页数：13

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