Mucin (Qniumucin), a glycoprotein from jellyfish, and determination of its main chain structure

被引:54
作者
Masuda, Akiko
Baba, Takayuki
Dohmae, Naoshi
Yamamura, Masahiro
Wada, Hiroo
Ushida, Kiminori
机构
[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 35101, Japan
[2] Shinwa Chem Ind Ltd, Fushimi Ku, Kyoto 6128307, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 07期
关键词
HUMAN GASTRIC MUCIN;
D O I
10.1021/np060341b
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%-3% dry weight, 0.02%-0.1% wet weight) and determined its main chain structure and molecular mass. The glycoprotein contains unique tandem repeats of eight amino acids, of which two threonine residues are probably glycosylated by N-acetyl-D-galactosamine (GalNAc). We named this substance, which is common in jellyfish and similar to the human mucin MUC5AC, "qniumucin" and suggested the utilization of this compound as a new marine resource.
引用
收藏
页码:1089 / 1092
页数:4
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