A comparative study of naproxen - Beta cyclodextrin complexes prepared by conventional methods and using Supercritical carbon dioxide

被引：53

作者：

Junco, S

Casimiro, T

Ribeiro, N

Da Ponte, MN

Marques, HC ^{[1
]}

机构：

[1] Univ Nova Lisboa, UCTF, Fac Farm, P-1200 Lisbon, Portugal

[2] Univ Nova Lisboa, REQUIMTE CQFB, Dept Quim, FCT, P-1200 Lisbon, Portugal

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2002年 / 44卷 / 1-4期

关键词：

beta-cyclodextrin; inclusion complexes; naproxen; supercritical carbon dioxide;

D O I：

10.1023/A:1023022008337

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Naproxen is a poorly soluble anti-inflammatory drug, the solubility of which can be enhanced by complexation with betacyclodextrin. Besides that, the inclusion complex reduces the incidence of gastrointestinal side effects of the drug. The aim of this work was to compare the physicochemical characteristics of the solid complexes prepared by traditional methods (kneading, freeze-drying and spray-drying) and using a supercritical fluid technology. The unusual solvent properties of carbon dioxide above their critical temperature and pressure were exploited in order to prepare inclusion compounds. Complexes prepared using supercritical fluid technology showed similar properties to those of freeze-drying and spray-drying complexes as proved by DSC, FT-IR and UV.

引用

页码：117 / 121

页数：5

共 8 条

[1]

BETTINETTI GP, 1989, FARMACO, V44, P195

[2] INFLUENCE OF METHOD OF PREPARATION ON INCLUSION COMPLEXES OF NAPROXEN WITH DIFFERENT CYCLODEXTRINS [J].