Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma

Purpose: The purpose of this study was to investigate the potential association between primary open-angle glaucoma and receptor of advanced glycation end products (AGER) polymorphisms in a Greek population. Methods: This is a case-control study of 106 patients with primary open-angle glaucoma and 120 healthy control subjects of Greek origin surveyed for AGER polymorphisms (rs1051993 and rs2070600) and a potential correlation to primary open-angle glaucoma. Results: AGER polymorphisms showed no statistically significant difference between patients with primary open-angle glaucoma and healthy controls. Conclusions: Our study did not find any significant association between AGER polymorphism and primary open-angle glaucoma. Since we cannot reject the possibility that oxidative stress is a crucial factor for the development of primary open-angle glaucoma, further studies may be needed to confirm the importance of the AGER gene in the glaucoma pathogenesis. (C) 2017 S. Karger AG, Basel