The role and potential application of extracellular vesicles in liver cancer

被引：16
作者：
Qi, Xuewei [1 ]
Chen, Shuzhen [2 ,3 ]
He, Huisi [2 ,3 ]
Wen, Wen [2 ,3 ]
Wang, Hongyang [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Affiliated Hosp 1, Canc Res Ctr, Div Life Sci & Med, Hefei 230026, Peoples R China
[2] Second Mil Med Univ, Natl Ctr Liver Canc, Shanghai 200438, Peoples R China
[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2021年 / 64卷 / 08期
基金：
中国国家自然科学基金;
关键词：
extracellular vesicles; exosomes; microvesicles; liver cancer; tumor microenvironment; noninvasive biomarker; EV-based therapy; HEPATOCELLULAR-CARCINOMA; CIRCULATING MICROPARTICLES; MEMBRANE-SCISSION; MOLECULAR-MECHANISMS; CELL-PROLIFERATION; EXOSOME SECRETION; MEDIATED TRANSFER; DENDRITIC CELLS; LUNG METASTASIS; MICROVESICLES;
D O I：
10.1007/s11427-020-1905-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Liver cancer is one of the most common causes of cancer-related death worldwide and mainly includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Extracellular vesicles (EVs) are membrane-derived nanometer-sized vesicles that can be released by different cell types under normal and pathological conditions and thus play important roles in the transmission of biological information between cells. Increasing evidence suggests that liver cancer cell-derived EVs may help establish a favorable microenvironment to support the proliferation, invasion and metastasis of cancer cells. In this review, we summarized the role of EVs in the tumor microenvironment (TME) during the development and progression of liver cancer. As messenger carriers, EVs are loaded by various biomolecules, such as proteins, RNA, DNA, lipids and metabolites, making them potential liquid biopsy biomarkers for the diagnosis and prognosis of liver cancer. We also highlighted the progress of EVs as antigen carriers and EV-based therapeutics in preclinical studies of liver cancer
引用
收藏
页码：1281 / 1294
页数：14
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