Dynamically Tunable Chemiluminescence of Luminol-Functionalized Silver Nanoparticles and Its Application to Protein Sensing Arrays

被引：67

作者：

He, Yi ^{[1
,2
]}

He, Xiao ^{[1
]}

Liu, Xiaoying ^{[1
]}

Gao, Lingfeng ^{[1
]}

Cui, Hua ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Collaborat Innovat Ctr Chem Energy Mat, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

[2] Southwest Univ Sci & Technol, Sch Natl Def Sci & Technol, Mianyang 621010, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2014年 / 86卷 / 24期

关键词：

SENSOR; DISCRIMINATION; IDENTIFICATION; GENERATION;

D O I：

10.1021/ac503123q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

It is still a great challenge to develop an array-based sensing system that can obtain only multiparameters, according to a single experiment and device. The role of conventional chemiluminescence (CL) in biosensing has been limited to a signal transducer in which a single signal (CL intensity) can be obtained for quantifying the concentrations of analytes. In this work, we have developed an dynamically tunable CL system, based on the reaction of luminol-functionalized silver nanoparticles (luminol-AgNPs) with H2O2, which could be tunable via adjusting various conditions such as the concentration of H2O2, pH value, and addition of protein. A single experiment operation could obtain multiparameters including CL intensity, the time to appear CL emission and the time to reach CL peak value. The tunable, low-background, and highly reproducible CL system based on luminol-AgNPs is applied, for the first time, as a sensing platform with trichannel properties for protein sensing arrays by principal component analysis. Identification of 35 unknowns demonstrated a success rate of >96%. The developed sensing arrays based on the luminol-AgNPs provide a new way to use nanoparticles-based CL for the fabrication of sensing arrays and hold great promise for biomedical application in the future.

引用

页码：12166 / 12171

页数：6

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