A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery

被引：25

作者：

Liu, S. ^{[1
,2
]}

Li, Y. ^{[1
,2
]}

Zhang, J. ^{[1
,2
]}

Zhang, H. ^{[1
,2
]}

Wang, Y. ^{[1
,2
]}

Chuah, C. ^{[5
]}

Tang, Y. ^{[5
]}

Lam, J. W. Y. ^{[1
,2
]}

Kwok, R. T. K. ^{[1
,2
]}

Ou, H. ^{[3
,4
]}

Ding, D. ^{[3
,4
]}

Tang, B. Z. ^{[1
,2
,6
,7
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Kowloon, Div Life Sci,Dept Chem,Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Biomed Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[3] Nankai Univ, Minist Educ, Key Lab Bioact Mat, Tianjin 300071, Peoples R China

[4] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

[5] Flinders Univ S Australia, Coll Sci & Engn, Inst NanoScale Sci & Technol, Bedford Pk, SA 5042, Australia

[6] South China Univ Technol, Ctr Aggregat Induced Emiss, SCUT HKUST Joint Res Inst, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China

[7] Guangzhou Dev Dist, AIE Inst, Guangzhou 510530, Peoples R China

来源：

MATERIALS TODAY BIO | 2021年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Aggregation-induced emission; Fluorescence; Image-guided surgery; Absorbance; Brightness; INTRAMOLECULAR CHARGE-TRANSFER; AGGREGATION-INDUCED EMISSION; INTRAOPERATIVE IDENTIFICATION; FLUORESCENCE; FLUOROPHORES; CANCER; BRIGHT; PROBE; DOTS;

D O I：

10.1016/j.mtbio.2020.100087

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Fluorescence imaging in the near-infrared II (NIR-II, 1000-1700 nm) region opens up new avenues for biological systems due to suppressed scattering and low autofluorescence at longer-wavelength photons. Nonetheless, the development of organic NIR-II fluorophores is still limited mainly due to the shortage of efficient molecular design strategy. Herein, we propose an approach of designing Janus NIR-II fluorophores by introducing electronic donors with distinct properties into one molecule. As a proof-of-concept, fluorescent dye 2 TT-m, oC6B with both twisted and planar electronic donors displayed balanced absorption and emission which were absent in its parent compound. The key design strategy for Janus molecule is that it combines the merits of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif. The resulting 2 TT-m, oC6B nanoparticles exhibit a high molar absorptivity of 1.12x10(4) M-1 cm(-1) at 808 nm and a NIR-II quantum yield of 3.7%, displaying a typical aggregation-induced emission (AIE) attribute. The highly bright and stable 2 TT-m, oC6B nanoparticles assured NIR-II image-guided cancer surgery to resect submillimeter tumor nodules. The present study may inspire further development of molecular design philosophy for highly bright NIR-II fluorophores for biomedical applications.

引用

页数：10

共 63 条

[1] Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy [J].