Seasonal prevalence and characteristics of low-dose CT detected lung nodules in a general Dutch population

被引：9

作者：

Lancaster, Harriet L. ^{[1
]}

Heuvelmans, Marjolein A. ^{[2
]}

Pelgrim, Gert Jan ^{[1
]}

Rook, Mieneke ^{[1
,3
]}

Kok, Marius G. J. ^{[1
]}

Aown, Ahmed ^{[1
]}

de Bock, Geertruida H. ^{[2
]}

van den Berge, Maarten ^{[4
]}

Groen, Harry J. M. ^{[4
]}

Vliegenthart, Rozemarijn ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[3] Martini Hosp Groningen, Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

CHRONIC RHINOSINUSITIS; CANCER; RISK; BENEFITS; HARMS;

D O I：

10.1038/s41598-021-88328-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated whether presence and characteristics of lung nodules in the general population using low-dose computed tomography (LDCT) varied by season. Imaging in Lifelines (ImaLife) study participants who underwent chest LDCT-scanning between October 2018 and October 2019 were included in this sub-study. Hay fever season (summer) was defined as 1st April to 30th September and Influenza season (winter) as 1st October to 31st March. All lung nodules with volume of >= 30 mm(3) (approximately 3 mm in diameter) were registered. In total, 2496 lung nodules were found in 1312 (38%) of the 3456 included participants (nodules per participant ranging from 1 to 21, median 1). In summer, 711 (54%) participants had 1 or more lung nodule(s) compared to 601 (46%) participants in winter (p=0.002). Of the spherical, perifissural and left-upper-lobe nodules, relatively more were detected in winter, whereas of the polygonal-, irregular-shaped and centrally-calcified nodules, relatively more were detected in summer. Various seasonal diseases with inflammation as underlying pathophysiology may influence presence and characteristics of lung nodules. Further investigation into underlying pathophysiology using short-term LDCT follow-up could help optimize the management strategy for CT-detected lung nodules in clinical practice.

引用

页数：10

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