5-Butylamino-2-[ 2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

被引：1
|
作者：
Xie, Li-Juan [1 ,2 ]
机构：
[1] Huaqiao Univ, Inst Mol Med, Quanzhou 362021, Fujian, Peoples R China
[2] State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷
关键词：
ACETYLATOR PHENOTYPE;
D O I：
10.1107/S1600536810018702
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits antitumor activity. The asymmetric unit contains two molecules with similar conformations for the substituted aliphatic chains. The two independent molecules form dmers through N-H center dot center dot center dot N hydrogen bonds. The crystal structure is stabilized via pi-pi stacking interactions, the shortest centroid-centroid separation between six-membered rings being 3.673 (2) angstrom.
引用
收藏
页码：O1454 / U1788
页数：14
相关论文
共 50 条
  • [11] Halocyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
    Zborovskii, Yu. L.
    Orysyk, V. V.
    Staninets, V. I.
    Bon', V. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 47 (06) : 881 - 885
  • [12] Halocyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
    Yu. L. Zborovskii
    V. V. Orysyk
    V. I. Staninets
    V. V. Bon’
    Russian Journal of Organic Chemistry, 2011, 47 : 881 - 885
  • [13] A theoretical investigation about sensing mechanism of fluoride anion for (E)-2-(2-(dimethylamino)ethyl)-6-(4-hydroxystyryl)-1H-benzo[de]-isoquinoline-1,3 (2H)-dione
    Song, Xiaoyan
    Yang, Guang
    Jia, Min
    Zhang, Qiaoli
    JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2018, 31 (09)
  • [14] Crystal structure of 2-(2,2,6,6-tetramethylpiperidin-4-yl)-6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione
    Pollock, Alicia A.
    Huther, Holly A.
    Birch, Cole M.
    Reinheimer, Eric W.
    Lewis, David E.
    Gerlach, Deidra L.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2022, 78 : 1161 - +
  • [15] 2-(2-Hydroxyethyl)-6-[(2-hydroxyethyl)amino]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
    Qin, Wen
    Zhang, Ye
    Wang, Heng-Shan
    Zhang, Yong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O3995 - U2523
  • [16] Synthesis and antimicrobial activity of derivatives of 1H-benzo[de]isoquinoline-1,3(2H)-dione
    Kuran, Bozena
    Krawiecka, Mariola
    Kossakowski, Jerzy
    Szymanek, Ksenia
    Kierzkowska, Marta
    Mlynarczyk, Grazyna
    HETEROCYCLIC COMMUNICATIONS, 2012, 18 (5-6) : 275 - 278
  • [17] 6-Bromo-2-(diprop-2-ynylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
    Lv, Jing-Song
    Wang, Jun-Lei
    Zhou, Cheng-He
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1852 - +
  • [18] Derivatives of 5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione: design, synthesis, and biological activity
    Aibin Wu
    Jide Liu
    Shaoxiong Qin
    Ping Mei
    Monatshefte für Chemie - Chemical Monthly, 2010, 141 : 95 - 99
  • [19] Derivatives of 5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione: design, synthesis, and biological activity
    Wu, Aibin
    Liu, Jide
    Qin, Shaoxiong
    Mei, Ping
    MONATSHEFTE FUR CHEMIE, 2010, 141 (01): : 95 - 99
  • [20] Novel luminescent hybrid materials by covalently anchoring 2-[3-(triethoxysilyl) propyl-1H-Benz [de]isoquinoline-1, 3(2H)-dione to bimodal mesoporous materials
    Li, Yuzhen
    Sun, Jihong
    Gao, Lin
    Wu, Xia
    Yang, Bo
    JOURNAL OF LUMINESCENCE, 2012, 132 (04) : 1076 - 1082
12345