5-Butylamino-2-[ 2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

被引：1

作者：

Xie, Li-Juan ^{[1
,2
]}

机构：

[1] Huaqiao Univ, Inst Mol Med, Quanzhou 362021, Fujian, Peoples R China

[2] State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷

关键词：

ACETYLATOR PHENOTYPE;

D O I：

10.1107/S1600536810018702

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits antitumor activity. The asymmetric unit contains two molecules with similar conformations for the substituted aliphatic chains. The two independent molecules form dmers through N-H center dot center dot center dot N hydrogen bonds. The crystal structure is stabilized via pi-pi stacking interactions, the shortest centroid-centroid separation between six-membered rings being 3.673 (2) angstrom.

引用

页码：O1454 / U1788

页数：14

共 50 条

[1] GENOTOXICITY OF 1H-BENZ DE ISOQUINOLINE-1,3(2H)-DIONE,5 AMINO-2-(DIMETHYAMINO) ETHYL (BIDA) IN HUMAN-LYMPHOCYTES
SAVARAJ, N
LIANG, J
LU, K
LOO, TL
HSU, TC
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1986, 27 : 283 - 283
[2] 2-[3-METHYLTHIOPROPYL]-1H-BENZ[D,E]ISOQUINOLINE-1,3(2H)-DIONE DERIVATIVES AS NOVEL PHOTOINDUCED DNA CLEAVERS
MATSUGO, S
NAKANO, S
ADACHI, K
KONISHI, T
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (03) : 311 - 312
[3] 2-(2-selenocyanic acid ethyl ester)-1H-benz[de] isoquinoline-1,3-(2H)-dione, synthesis photophysics and interaction with bovine serum albumin:: A spectroscopic approach
Ghosh, SK
Hossain, SU
Bhattacharya, S
Bhattacharya, SC
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2005, 81 (02) : 121 - 128
[4] GENOTOXICITY OF [H-1]BENZ [DE] ISOQUINOLINE-1, 3[H-2]DIONE, 5 AMINO-2-(DIMETHYLAMINO), [2-(DIMETHYLAMINO)ETHYL] (BIDA) IN HUMAN-LYMPHOCYTES
SAVARAJ, N
LIANG, J
LU, K
FEUN, LG
HSU, TC
CANCER INVESTIGATION, 1989, 7 (02) : 117 - 121
[5] 2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione
Ishikawa, Yoshinobu
Matsuo, Soichiro
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O1311 - +
[6] Alkylation of 1H-benz[de]isoquinoline-1,3(2H)dione and benz[cd]indol-2(1H)one under conditions of phase-transfer catalysis
Anikin, V.F., 1600, Maik Nauka-Interperiodica Publishing (73):
[7] Alkylation of 1H-benz[de]isoquinoline-1,3(2H)dione and benz[cd]indol-2(1H)one under conditions of phase-transfer catalysis
Anikin, VF
Krasnova, EA
Kupriyan, DG
RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2000, 73 (03) : 486 - 489
[8] Catalysis in Transamination of 6-chloro-2-(3-chlorophenyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione and its Implications in Laser Tissue Welding
Anderson, Samantha M.
Mitchell, Stanford D.
LaPlante, Kayla A.
McKenney, Ryan K.
Lewis, David E.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (03) : 2029 - 2037
[9] 2-Benzyl-6-(benzylamino)-1H-benzo-[de]isoquinoline-1,3(2H)-dione
Zhang, Ye
Han, Gui-Ming
Wu, Qiang
Wang, Heng-Shan
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O4336 - U3561
[10] Identification and characterization of in vitro metabolites of 2-[2′-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-dione (azonafide)
Mayr, CA
Sami, SM
Remers, WA
Dorr, RT
DRUG METABOLISM AND DISPOSITION, 1998, 26 (02) : 105 - 109

← 1 2 3 4 5 →