Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides

被引：12

作者：

Nam, Ghilsoo ^{[1
]}

Kim, Yang Soo ^{[2
]}

Choi, Kyung Il ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Neuromed Res Ctr, Life & Hlth Div, 5 Wolsong Gil, Seoul 136791, South Korea

[2] Asan Med Ctr, Infect Dis Res Ctr, Seoul 138736, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 08期

关键词：

Ketolides; Macrolide antibiotics; 9-O-Arylpropenyloximes; Antibacterial activity; STREPTOCOCCUS-PNEUMONIAE; TELITHROMYCIN; SUSCEPTIBILITY; DERIVATIVES; RESISTANT;

D O I：

10.1016/j.bmcl.2010.01.153

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 9-O-arylpropenyloxime ketolide was synthesized and evaluated for their antibacterial activity. This series of ketolide exhibited potent activity against clinically isolated gram-positive strains including Staphylococcus pneumoniae and Straptococcus Pyogenes. (C) 2010 Published by Elsevier Ltd.

引用

页码：2671 / 2674

页数：4

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