Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display

被引：28
作者：
Peacock, Hayden [1 ]
Suga, Hiroaki [1 ]
机构：
[1] Univ Tokyo, Grad Sch Sci, Dept Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2021年 / 42卷 / 05期
关键词：
IN-VITRO SELECTION; D-AMINO ACIDS; RIBOSOMAL SYNTHESIS; CYCLIC-PEPTIDES; PROTEIN SURFACES; LIBRARIES; INHIBITORS; LIGANDS; THERAPEUTICS; CYCLIZATION;
D O I：
10.1016/j.tips.2021.02.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Macrocyclic peptides are a promising class of compounds that can often engage challenging therapeutic targets. Display technologies, such as mRNA display, allow for the efficient discovery of macrocyclic peptides. This article reviews the current approaches for generating macrocyclic peptide libraries using mRNA display and highlights some recent examples of ribosomal incorporation of nonproteinogenic amino acids into macrocyclic peptides.
引用
收藏
页码：385 / 397
页数：13
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