Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: Novel ligands for the estrogen receptor

被引：214
作者：
Huang, YR [1 ]
Katzenellenbogen, JA [1 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 18期
关键词：
D O I：
10.1021/ol0062650
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor.
引用
收藏
页码：2833 / 2836
页数：4
相关论文
共 19 条
  • [1] The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site
    Anstead, GM
    Carlson, KE
    Katzenellenbogen, JA
    [J]. STEROIDS, 1997, 62 (03) : 268 - 303
  • [2] HYDROXYLATED 2,3-DIARYLINDENES - SYNTHESIS, ESTROGEN-RECEPTOR BINDING-AFFINITY, AND BINDING ORIENTATION CONSIDERATIONS
    ANSTEAD, GM
    PETERSON, CS
    KATZENELLENBOGEN, JA
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1989, 33 (05) : 877 - 887
  • [3] ELGUERO J, 1970, B SOC CHIM FR, P3466
  • [4] Elguero J., 1996, COMPREHENSIVE HETERO, V3, P1, DOI DOI 10.1016/B978-008096518-5.00059-9
  • [5] Elguero J., 1997, COMPREHENSIVE HETERO, V5, P167, DOI DOI 10.1016/B978-008096519-2.00072-2
  • [6]
    [Z].
  • [7] Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens
    Fink, BE
    Mortensen, DS
    Stauffer, SR
    Aron, ZD
    Katzenellenbogen, JA
    [J]. CHEMISTRY & BIOLOGY, 1999, 6 (04): : 205 - 219
  • [8] Grese TA, 1998, CURR PHARM DESIGN, V4, P71
  • [9] GUPTA S, 1995, INDIAN J CHEM B, V34, P245
  • [10] NMR SPECTRA AND STEREOISOMERISM IN PYRAZOLINES
    HASSNER, A
    MICHELSON, MJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (11) : 3974 - &
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