Chiral Selector as a Tool for Determination of Enantiomeric Ratio in Mixture by Molecular Spectroscopy with Multivariate Calibration

This review provides brief information on using the chiral selector in a new approach to chiral analysis, that is, a combination of molecular spectroscopy with multivariate calibration. This new approach provides a more rapid, more sensitive and cheaper chiral analysis of many compounds, as compared to the traditional chiral methods. The interaction between the chiral selector and the enantiomers forms a diastereomeric complex, which causes the occurrence of the spectral shifts. These shifts are small and they must be evaluated by multivariate calibration.